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Gene Review:

GlyP - Glycogen phosphorylase

Drosophila melanogaster

Synonyms: BcDNA:LD24485, CG7254, DGPH, Dmel\CG7254, GP, ...

Tick, G. et al., LaMarco, K. et al., Dombrádi, V. et al.

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High impact information on GlyP

The sequences of these repeats are similar to repeats in several transmembrane proteins, including Notch from Drosophila melanogaster and Glp-1 and Lin-12 from Caenorhabditis elegans [1].
Comparison of the conceptual amino acid sequence of the Drosophila glycogen phosphorylase with glycogen phosphorylase sequences from other organisms shows a high degree of homology to mammalian enzymes [2].
The DGPH gene has been cloned and sequenced; its open reading frame codes for a protein of 844 amino acids with a predicted molecular mass of 97 kDa [2].
Glycogen phosphorylase isolated from Drosophila melanogaster contains one pyridoxal 5'-phosphate per subunit; the coenzyme is in a hydrophobic environment [3].

References

Identification of Ets- and notch-related subunits in GA binding protein. LaMarco, K., Thompson, C.C., Byers, B.P., Walton, E.M., McKnight, S.L. Science (1991) [Pubmed]
Structural and functional characterization of the Drosophila glycogen phosphorylase gene. Tick, G., Cserpán, I., Dombrádi, V., Mechler, B.M., Török, I., Kiss, I. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
Structural and functional properties of Drosophila melanogaster phosphorylase: comparison with the rabbit skeletal muscle enzyme. Dombrádi, V., Matkó, J., Kiss, Z., Kiss, L., Friedrich, P., Bot, G. Comp. Biochem. Physiol., B (1986) [Pubmed]

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