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Gene Review

Pygm  -  muscle glycogen phosphorylase

Mus musculus

Synonyms: AI115133, Glycogen phosphorylase, muscle form, Myophosphorylase, PG
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High impact information on Pygm

  • The genes encoding muscle, liver, and brain phosphorylases (Pygm, Pygl, and Pygb) are assigned to mouse chromosomes 19, 12, and 2, respectively [1].
  • A new class of diacid analogues that binds at the AMP site not only are very potent but have approximately 10-fold selectivity in liver versus muscle glycogen phosphorylase (GP) in the in vitro assay [2].
  • Three of the E box motifs in the MGP proximal promoter interacted with C2C12 nuclear proteins [3].
  • Role of E and CArG boxes in developmental regulation of muscle glycogen phosphorylase promoter during myogenesis [3].
  • Native MGP transcripts were not detected in pluripotent CH310T1/2 fibroblasts, but low levels of MGP mRNA were measured in CH310T1/2 cells that were stably transfected with MyoD [3].

Anatomical context of Pygm

  • Previous studies demonstrated that a 269 bp region 5' to exon 1 of MGP is sufficient for developmental regulation in the C2C12 myogenic cell line (Froman et al., 1994) [3].
  • Mutational analyses of the MGP promoter demonstrated that increased expression in C2C12 myotubes did not require any of the E box motifs or the CArG-like element [3].
  • Muscle glycogen phosphorylase (MGP) transcript and protein levels increase during skeletal muscle development in tandem with the products of other muscle genes responsible for glucose and glycogen metabolism [3].

Associations of Pygm with chemical compounds


  1. Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively. Glaser, T., Matthews, K.E., Hudson, J.W., Seth, P., Housman, D.E., Crerar, M.M. Genomics (1989) [Pubmed]
  2. A new class of glycogen phosphorylase inhibitors. Lu, Z., Bohn, J., Bergeron, R., Deng, Q., Ellsworth, K.P., Geissler, W.M., Harris, G., McCann, P.E., McKeever, B., Myers, R.W., Saperstein, R., Willoughby, C.A., Yao, J., Chapman, K. Bioorg. Med. Chem. Lett. (2003) [Pubmed]
  3. Role of E and CArG boxes in developmental regulation of muscle glycogen phosphorylase promoter during myogenesis. Froman, B.E., Tait, R.C., Gorin, F.A. DNA Cell Biol. (1998) [Pubmed]
  4. The turnover of skeletal muscle glycogen phosphorylase studied using the cofactor, pyridoxal phosphate, as a specific label. Butler, P.E., Cookson, E.J., Beynon, R.J. Biochim. Biophys. Acta (1985) [Pubmed]
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