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Gene Review:

nad2 - NADH dehydrogenase subunit 2

Arabidopsis thaliana

Lippok, B. et al., Lutz, K.A. et al.

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High impact information on nad2

In its mitochondrial counterpart, nad2, 31 editing sites are present, none of which are shared with the ndhB gene [1].
The editing sites in the Arabidopsis nad2 and nad4 mRNAs have previously been determined and we report here 19 editing sites in eight mRNAs in Arabidopsis plastids [1].
In the second nad2 coding region (exons c-e) a pseudo tRNA(Tyr) sequence and a fragment of the plastid psbA gene are located upstream of the trans-spliced exon c. Primer extension analysis identifies RNA 5'-termini within the pseudo-tRNA(Tyr) confirming this sequence to be non-functional [2].
In Arabidopsis mitochondria the nad2-gene consists of five exons (a-e) which are separated by three cis-splicing introns and one trans-splicing intron [2].
The rps4 and nad2 coding sequences as well as the first cis-intron and the trans-intron sequences of the nad2 gene are altered by RNA editing [2].

Analytical, diagnostic and therapeutic context of nad2

Northern blot analysis suggests the rps4-gene to be cotranscribed with at least the first part of the nad2-gene [2].

References

Lack of conservation of editing sites in mRNAs that encode subunits of the NAD(P)H dehydrogenase complex in plastids and mitochondria of Arabidopsis thaliana. Lutz, K.A., Maliga, P. Curr. Genet. (2001) [Pubmed]
The rps4-gene is encoded upstream of the nad2-gene in Arabidopsis mitochondria. Lippok, B., Brennicke, A., Unseld, M. Biol. Chem. Hoppe-Seyler (1996) [Pubmed]

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