Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

nompC - no mechanoreceptor potential C

Drosophila melanogaster

Synonyms: CG11020, CG17468, CT30855, DmNompC, Dmel\CG11020, ...

Sidi, S. et al., Kim, J. et al., Walker, R.G. et al., Howard, J. et al.

Howard, Bechstedt,

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High impact information on nompC

Loss-of-function mutations in the no mechanoreceptor potential C (nompC) gene virtually abolished mechanosensory signaling. nompC encodes a new ion channel that is essential for mechanosensory transduction [1].
Hypothesis: a helix of ankyrin repeats of the NOMPC-TRP ion channel is the gating spring of mechanoreceptors [2].
Here we report that the zebrafish ortholog of Drosophila no mechanoreceptor potential C (nompC), which encodes a transient receptor potential (TRP) channel, is critical for HC mechanotransduction [3].
Morpholino-mediated removal of nompC function eliminated transduction-dependent endocytosis and electrical responses in HCs, resulting in larval deafness and imbalance [3].

Analytical, diagnostic and therapeutic context of nompC

Drosophila that are mutant for NOMPC, a transient receptor potential (TRP) superfamily ion channel, lack receptor potentials and currents in tactile bristles but retain most of the antennal sound-evoked response, suggesting that a different channel is the primary transducer in chordotonal organs [4].

References

A Drosophila mechanosensory transduction channel. Walker, R.G., Willingham, A.T., Zuker, C.S. Science (2000) [Pubmed]
Hypothesis: a helix of ankyrin repeats of the NOMPC-TRP ion channel is the gating spring of mechanoreceptors. Howard, J., Bechstedt, S. Curr. Biol. (2004) [Pubmed]
NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. Sidi, S., Friedrich, R.W., Nicolson, T. Science (2003) [Pubmed]
A TRPV family ion channel required for hearing in Drosophila. Kim, J., Chung, Y.D., Park, D.Y., Choi, S., Shin, D.W., Soh, H., Lee, H.W., Son, W., Yim, J., Park, C.S., Kernan, M.J., Kim, C. Nature (2003) [Pubmed]

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