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MeSH Review:

Mechanotransduction, Cellular

Cockayne, D.A. et al., Langevin, H.M. et al., Walker, R.G. et al., Jones, J.C. et al., Wilson, L.J. et al., et al.

Jones, Lane, Hopkinson, Lecuona, Geiger, Dean, Correa-Meyer, Gonzales, Campbell, Sznajder, Budinger, Cockayne, Dunn, Zhong, Rong, Hamilton, Knight, Ruan, Ma, Yip, Nunn, McMahon, Burnstock, Ford, Langevin, Storch, Cipolla, White, Buttolph, Taatjes,

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High impact information on Mechanotransduction, Cellular

Mechanosensory transduction in touch receptor neurons is believed to be mediated by DEG/ENaC (degenerin/epithelial Na+ channel) proteins in nematodes and mammals [1].
Loss-of-function mutations in the no mechanoreceptor potential C (nompC) gene virtually abolished mechanosensory signaling. nompC encodes a new ion channel that is essential for mechanosensory transduction [2].
These and other observations lead us to propose that extracellular, but not cytoskeletal, tethering of the degenerin channel is needed for mechanosensory transduction [3].
CONCLUSIONS: Adenosine 5'-triphosphate contributes to mechanosensory transduction in the rat colorectum, and this is probably associated with pain [4].
Laminin-6 assembles into multimolecular fibrillar complexes with perlecan and participates in mechanical-signal transduction via a dystroglycan-dependent, integrin-independent mechanism [5].

Biological context of Mechanotransduction, Cellular

Inhibiting the major mechanical signal transduction pathway with the ERK inhibitor, U0126, blocked upregulation of gene expression [6].

Anatomical context of Mechanotransduction, Cellular

This dual response pattern of alpha- and beta-actin may be an important component of cellular mechanotransduction mechanisms relevant to physiologic and therapeutic mechanical forces applied to connective tissue [7].

Associations of Mechanotransduction, Cellular with chemical compounds

Nitric oxide (NO) is believed to play a role in mechanical signal transduction, and there is also significant evidence of its role in cartilage and meniscus degeneration [8].

Gene context of Mechanotransduction, Cellular

Taken together, these data extend our findings for P2X3-/- mice, and reveal an important contribution of heteromeric P2X2/3 receptors to nociceptive responses and mechanosensory transduction within the urinary bladder [9].
Since they change shape when the elastic strand is stretched, which compresses the extracellular matrix of the partitions, they are probably the site of mechanosensory transduction [10].

References

The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel. Chelur, D.S., Ernstrom, G.G., Goodman, M.B., Yao, C.A., Chen, L., O' Hagan, R., Chalfie, M. Nature (2002) [Pubmed]
A Drosophila mechanosensory transduction channel. Walker, R.G., Willingham, A.T., Zuker, C.S. Science (2000) [Pubmed]
Extracellular proteins organize the mechanosensory channel complex in C. elegans touch receptor neurons. Emtage, L., Gu, G., Hartwieg, E., Chalfie, M. Neuron (2004) [Pubmed]
Purinergic mechanisms contribute to mechanosensory transduction in the rat colorectum. Wynn, G., Rong, W., Xiang, Z., Burnstock, G. Gastroenterology (2003) [Pubmed]
Laminin-6 assembles into multimolecular fibrillar complexes with perlecan and participates in mechanical-signal transduction via a dystroglycan-dependent, integrin-independent mechanism. Jones, J.C., Lane, K., Hopkinson, S.B., Lecuona, E., Geiger, R.C., Dean, D.A., Correa-Meyer, E., Gonzales, M., Campbell, K., Sznajder, J.I., Budinger, S. J. Cell. Sci. (2005) [Pubmed]
Increased transcriptional response to mechanical strain in keloid fibroblasts due to increased focal adhesion complex formation. Wang, Z., Fong, K.D., Phan, T.T., Lim, I.J., Longaker, M.T., Yang, G.P. J. Cell. Physiol. (2006) [Pubmed]
Fibroblast spreading induced by connective tissue stretch involves intracellular redistribution of alpha- and beta-actin. Langevin, H.M., Storch, K.N., Cipolla, M.J., White, S.L., Buttolph, T.R., Taatjes, D.J. Histochem. Cell Biol. (2006) [Pubmed]
The effect of dynamic mechanical compression on nitric oxide production in the meniscus. Fink, C., Fermor, B., Weinberg, J.B., Pisetsky, D.S., Misukonis, M.A., Guilak, F. Osteoarthr. Cartil. (2001) [Pubmed]
P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP. Cockayne, D.A., Dunn, P.M., Zhong, Y., Rong, W., Hamilton, S.G., Knight, G.E., Ruan, H.Z., Ma, B., Yip, P., Nunn, P., McMahon, S.B., Burnstock, G., Ford, A.P. J. Physiol. (Lond.) (2005) [Pubmed]
Functional morphology of the telson-uropod stretch receptor in the sand crab Emerita analoga. Wilson, L.J., Paul, D.H. J. Comp. Neurol. (1990) [Pubmed]

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