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Gene Review

eIF-4a  -  Eukaryotic initiation factor 4a

Drosophila melanogaster

Synonyms: 2439, 9075, ATP-dependent RNA helicase eIF4A, CG9075, Dm-eIF4A, ...
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Disease relevance of eIF-4a

  • Among these proteins are eIF-4A, an essential component of the cap-binding complex, numerous yeast proteins required for pre-mRNA splicing, and proteins from yeast and E. coli necessary for ribosome assembly [1].

High impact information on eIF-4a


Biological context of eIF-4a

  • The two mRNAs contain the same open reading frame and produce the identical eIF4A protein [5].
  • We observed ubiquitous expression of eIF4A mRNA and protein during Drosophila embryogenesis [5].
  • A combination of immunoblotting and labelling with [(35)S]methionine + [(35)S]cysteine revealed the existence of a single eIF4A isoform encoded by a previously reported gene that maps to chromosome 2L at 26A7-9 [5].

Other interactions of eIF-4a

  • Yeast two-hybrid analysis demonstrated the in vivo interaction of Drosophila eIF4G with the N-terminal third of eIF4A [5].

Analytical, diagnostic and therapeutic context of eIF-4a


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