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Gene Review:

EIF4A2 - eukaryotic translation initiation factor 4A2

Homo sapiens

Synonyms: ATP-dependent RNA helicase eIF4A-2, BM-010, DDX2B, EIF4A, EIF4F, ...

Cheyssac, C. et al., Sudo, K. et al., Kyono, K. et al.

Kyono, Miyashiro, Taguchi,

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Disease relevance of EIF4A2

Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro [1].

High impact information on EIF4A2

The potential role of EIF4A2 in glucose homeostasis and its putative contribution to type 2 diabetes in the presence of metabolic stress will require further investigation [2].
EIF4A2 controls specific mRNA translation and protein synthesis rate in pancreatic beta-cells, and our data indicates that EIF4A2 is downregulated by high glucose in rat beta-INS832/13 cells [2].
Furthermore, we have localized the human EIF4A2 to chromosome 18p11.2 by fluorescent in situ hybridization [3].

References

Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro. Kyono, K., Miyashiro, M., Taguchi, I. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families. Cheyssac, C., Dina, C., Leprêtre, F., Vasseur-Delannoy, V., Dechaume, A., Lobbens, S., Balkau, B., Ruiz, J., Charpentier, G., Pattou, F., Joly, E., Prentki, M., Hansen, T., Pedersen, O., Vaxillaire, M., Froguel, P. Diabetes (2006) [Pubmed]
Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2. Sudo, K., Takahashi, E., Nakamura, Y. Cytogenet. Cell Genet. (1995) [Pubmed]

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AgaP_AGAP009863	Anopheles gambiae str. PEST
EIF4A-2	Arabidopsis thaliana
EIF4A1	Arabidopsis thaliana
EIF4A2	Bos taurus
inf-1	Caenorhabditis elegans
EIF4A2	Canis lupus familiaris
eIF-4a	Drosophila melanogaster
EIF4A2	Gallus gallus
EIF4A2	Macaca mulatta
Eif4a2	Mus musculus
Os02g0146600	Oryza sativa Japonica Group
Os06g0701100	Oryza sativa Japonica Group
EIF4A2	Pan troglodytes
Eif4a2	Rattus norvegicus

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