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Gene Review

pgc  -  polar granule component

Drosophila melanogaster

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High impact information on pgc

  • This polar granule component shows significant sequence similarity to eIF-4A, a translation initiation factor that binds to mRNA, and to other helicases [1].
  • Most pole cells in embryos produced by transgenic females expressing antisense Pgc RNA failed to complete migration and to populate the embryonic gonads, and females that developed from these embryos often had agametic ovaries [2].
  • Consistently, pole cells compromised for pgc function exhibit elevated levels of activated MAP kinase and premature transcription of the target gene tailless (tll) [3].
  • In addition, we found that Aubergine was recruited to the posterior pole in a vas-dependent manner and is itself a polar granule component [4].
  • Aubergine encodes a Drosophila polar granule component required for pole cell formation and related to eIF2C [4].

Biological context of pgc


Anatomical context of pgc

  • This family has more than 40 members, including the eukaryotic translation initiation factor-4A (eIF-4A), the human nuclear protein p68, and the Drosophila oocyte polar granule component vasa [8].


  1. A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases. Hay, B., Jan, L.Y., Jan, Y.N. Cell (1988) [Pubmed]
  2. Requirement for a noncoding RNA in Drosophila polar granules for germ cell establishment. Nakamura, A., Amikura, R., Mukai, M., Kobayashi, S., Lasko, P.F. Science (1996) [Pubmed]
  3. Overlapping mechanisms function to establish transcriptional quiescence in the embryonic Drosophila germline. Deshpande, G., Calhoun, G., Schedl, P. Development (2004) [Pubmed]
  4. Aubergine encodes a Drosophila polar granule component required for pole cell formation and related to eIF2C. Harris, A.N., Macdonald, P.M. Development (2001) [Pubmed]
  5. A noncoding RNA is required for the repression of RNApolII-dependent transcription in primordial germ cells. Martinho, R.G., Kunwar, P.S., Casanova, J., Lehmann, R. Curr. Biol. (2004) [Pubmed]
  6. Combinatorial RNA interference indicates GLH-4 can compensate for GLH-1; these two P granule components are critical for fertility in C. elegans. Kuznicki, K.A., Smith, P.A., Leung-Chiu, W.M., Estevez, A.O., Scott, H.C., Bennett, K.L. Development (2000) [Pubmed]
  7. Ultrastructure of E1 + 2 + 9 + 12 inversion breakpoints in Drosophila subobscura. Cuenca, J.B., Saura, A.O., Sorsa, V., de Frutos, R. Biol. Cell (1990) [Pubmed]
  8. The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family. Peelman, L.J., Chardon, P., Nunes, M., Renard, C., Geffrotin, C., Vaiman, M., Van Zeveren, A., Coppieters, W., van de Weghe, A., Bouquet, Y. Genomics (1995) [Pubmed]
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