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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PRSS53  -  protease, serine, 53

Homo sapiens

Synonyms: POL3S, Polyserase-3, Polyserine protease 3, Serine protease 53, UNQ308
 
 
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High impact information on POL3S

  • Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain [1].
  • Comparative analysis of polyserase-3 with the two human polyserases described to date, revealed that this novel polyprotein is more closely related to polyserase-2 than to polyserase-1 [1].
  • Enzymatic assays indicated that recombinant polyserase-3 degrades the alpha-chain of fibrinogen as well as pro-urokinase-type plasminogen activator (pro-uPA) [1].
  • Northern blot analysis showed that polyserase-3 exhibits a unique expression pattern among human polyserases, being predominantly detected in testis, liver, heart and ovary, as well as in several tumor cell lines [1].

References

  1. Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain. Cal, S., Peinado, J.R., Llamazares, M., Quesada, V., Moncada-Pazos, A., Garabaya, C., López-Otín, C. BMC Biochem. (2006) [Pubmed]
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