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Gene Review

Comp  -  cartilage oligomeric matrix protein

Mus musculus

Synonyms: COMP, Cartilage oligomeric matrix protein, TSP5, thrombospondin-5
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Disease relevance of Comp


High impact information on Comp


Biological context of Comp


Anatomical context of Comp


Associations of Comp with chemical compounds

  • In addition, it was demonstrated that, similarly to modified cortical endings (Hámori et al., J. Comp. Neurol. 254:166-183, '86), many GABA positive terminals appeared as specific afferent endings, replacing the missing "specific" vibrissal afferents [13].
  • This alternative approach to physiologically characterize neurons in the retina was introduced by Marc (1999, J Comp Neurol 407:47-64, 407:65-76), and allows the simultaneous mapping of responses of glutamate receptor-gated channels from an entire population of neurons [14].
  • Within the CN, the MOC collaterals tended to ramify in and near regions with high densities of granule cells, regions also associated with the terminals of type II afferent axons (Brown et al.: J. Comp. Neurol. 278:581-590, '88) [15].
  • The activity of 2,2'-dicarbomethoxyamino-5,5'-dibenzimidazolyl ketone (II, C.D.R.I. Comp. 82/437) has been evaluated for its micro- and macro-filaricidal efficacy against Litomosoides carinii in rodents [16].
  • 2-Phenyl-1H-phenantro [9, 10-d] imidazole (comp.1) and 2-(4-chlorophenyl)-1H-phenantro [9, 10-d] imidazole (comp. 6) were found to be more active than the others and their LD50 values were found to be greater than 100 mg/kg (i.p.) [17].

Other interactions of Comp


Analytical, diagnostic and therapeutic context of Comp


  1. Cartilage oligomeric matrix protein-deficient mice have normal skeletal development. Svensson, L., Aszódi, A., Heinegård, D., Hunziker, E.B., Reinholt, F.P., Fässler, R., Oldberg, A. Mol. Cell. Biol. (2002) [Pubmed]
  2. Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis. Liu, C.J., Prazak, L., Fajardo, M., Yu, S., Tyagi, N., Di Cesare, P.E. J. Biol. Chem. (2004) [Pubmed]
  3. Pathogenicity of different baboon herpesvirus papio 2 isolates is characterized by either extreme neurovirulence or complete apathogenicity. Rogers, K.M., Ealey, K.A., Ritchey, J.W., Black, D.H., Eberle, R. J. Virol. (2003) [Pubmed]
  4. Runx3 is essential for the target-specific axon pathfinding of trkc-expressing dorsal root ganglion neurons. Inoue, K., Ozaki, S., Ito, K., Iseda, T., Kawaguchi, S., Ogawa, M., Bae, S.C., Yamashita, N., Itohara, S., Kudo, N., Ito, Y. Blood Cells Mol. Dis. (2003) [Pubmed]
  5. Methyl 5(6)-4-2-pyridyl piperazino carbamoyl benzimidazole-2-carbamate--a new broad spectrum anthelmintic. Katiyar, J.C., Visen, P.K., Misra, A., Gupta, S., Bhaduri, A.P. Acta Trop. (1984) [Pubmed]
  6. COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model. Cho, C.H., Sung, H.K., Kim, K.T., Cheon, H.G., Oh, G.T., Hong, H.J., Yoo, O.J., Koh, G.Y. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  7. Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis. Cho, C.H., Kammerer, R.A., Lee, H.J., Yasunaga, K., Kim, K.T., Choi, H.H., Kim, W., Kim, S.H., Park, S.K., Lee, G.M., Koh, G.Y. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  8. "Peptabody": a new type of high avidity binding protein. Terskikh, A.V., Le Doussal, J.M., Crameri, R., Fisch, I., Mach, J.P., Kajava, A.V. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  9. Altered integration of matrilin-3 into cartilage extracellular matrix in the absence of collagen IX. Budde, B., Blumbach, K., Ylöstalo, J., Zaucke, F., Ehlen, H.W., Wagener, R., Ala-Kokko, L., Paulsson, M., Bruckner, P., Grässel, S. Mol. Cell. Biol. (2005) [Pubmed]
  10. A silencer element in the cartilage oligomeric matrix protein gene regulates chondrocyte-specific expression. Issack, P.S., Liu, C.J., Prazak, L., Di Cesare, P.E. J. Orthop. Res. (2004) [Pubmed]
  11. Molecular cloning, sequencing, and tissue and developmental expression of mouse cartilage oligomeric matrix protein (COMP). Fang, C., Carlson, C.S., Leslie, M.P., Tulli, H., Stolerman, E., Perris, R., Ni, L., Di Cesare, P.E. J. Orthop. Res. (2000) [Pubmed]
  12. Distribution of cartilage molecules in the developing mouse joint. Murphy, J.M., Heinegård, R., McIntosh, A., Sterchi, D., Barry, F.P. Matrix Biol. (1999) [Pubmed]
  13. Plasticity of GABA- and glutamate-containing terminals in the mouse thalamic ventrobasal complex deprived of vibrissal afferents: an immunogold-electron microscopic study. Hámori, J., Takács, J., Verley, R., Petrusz, P., Farkas-Bargeton, E. J. Comp. Neurol. (1990) [Pubmed]
  14. Mapping glutamate responses in immunocytochemically identified neurons of the mouse retina. Sun, D., Kalloniatis, M. J. Comp. Neurol. (2006) [Pubmed]
  15. Brainstem branches from olivocochlear axons in cats and rodents. Brown, M.C., Liberman, M.C., Benson, T.E., Ryugo, D.K. J. Comp. Neurol. (1988) [Pubmed]
  16. 2,2'-Dicarbomethoxyamino-5,5'-dibenzimidazolyl ketone--a new antifilarial agent. Fatma, N., Sharma, S., Chatterjee, R.K. Acta Trop. (1989) [Pubmed]
  17. Synthesis and analgesic activities of 2-substituted-1H-phenantro [9,10-d] imidazoles. Isikdağ, I., Uçucu, U., Ozdemir, A., Meriç, A., Oztürk, Y., Aydin, S., Ergun, B. Bollettino chimico farmaceutico. (1999) [Pubmed]
  18. Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina. de Melo, J., Qiu, X., Du, G., Cristante, L., Eisenstat, D.D. J. Comp. Neurol. (2003) [Pubmed]
  19. Genetic analysis of cerebellar folial pattern in crosses of C57BL/6J and DBA/2J inbred mice. Neumann, P.E., Garretson, J.D., Skabardonis, G.P., Mueller, G.G. Brain Res. (1993) [Pubmed]
  20. Role of IGFBPs in the morphogenesis of lingual papillae. Suzuki, Y. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. (2005) [Pubmed]
  21. Identity of esterase-22 and egasyn, the protein which complexes with microsomal beta-glucuronidase. Medda, S., von Deimling, O., Swank, R.T. Biochem. Genet. (1986) [Pubmed]
  22. Programmed cell death is a universal feature of embryonic and postnatal neuroproliferative regions throughout the central nervous system. Blaschke, A.J., Weiner, J.A., Chun, J. J. Comp. Neurol. (1998) [Pubmed]
  23. Developmental regulation of sensory neuron number and limb innervation in the mouse. Berg, J.S., Farel, P.B. Brain Res. Dev. Brain Res. (2000) [Pubmed]
  24. Up-regulation of cartilage oligomeric matrix protein at the onset of articular cartilage degeneration in a transgenic mouse model of osteoarthritis. Salminen, H., Perälä, M., Lorenzo, P., Saxne, T., Heinegård, D., Säämänen, A.M., Vuorio, E. Arthritis Rheum. (2000) [Pubmed]
  25. Molecular cloning and expression patterns of mouse cartilage oligomeric matrix protein gene. Kipnes, J.R., Xu, L., Han, F., Rallapalli, R., Jimenez, S., Hall, D.J., Tuan, R.S., Li, Y. Osteoarthr. Cartil. (2000) [Pubmed]
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