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Gene Review:

myoC - class I myosin

Dictyostelium discoideum AX4

Temesvari, L.A. et al., De La Roche, M.A. et al.

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High impact information on myoC

No alteration in contractile vacuole structure or function was observed in the myoB-, myoC- or myoB-/C- cell lines [1].
Sequence analysis of the MyoD light chain showed it to be a unique protein, termed MlcD, that shares 44% sequence identity with Dictyostelium calmodulin and 43% sequence identity with Acanthamoeba castellanii myosin IC light chain [2].

Biological context of myoC

Various properties of the endosomal pathway in the myoB-/C- double mutant as well as in the myoB- and myoC- single mutants, including intravesicular pH, and intracellular retention time and exocytosis of a fluid phase marker, were found to be indistinguishable from wild-type parental cells [1].

References

Examination of the endosomal and lysosomal pathways in Dictyostelium discoideum myosin I mutants. Temesvari, L.A., Bush, J.M., Peterson, M.D., Novak, K.D., Titus, M.A., Cardelli, J.A. J. Cell. Sci. (1996) [Pubmed]
The Dictyostelium class I myosin, MyoD, contains a novel light chain that lacks high-affinity calcium-binding sites. De La Roche, M.A., Lee, S.F., Côté, G.P. Biochem. J. (2003) [Pubmed]

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