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Disease relevance of Acanthamoeba


Psychiatry related information on Acanthamoeba


High impact information on Acanthamoeba

  • We have cloned the chickadee gene and found that cDNA clones encode a protein 40% identical to yeast and Acanthamoeba profilin [7].
  • Study of mutated yeast profilins and profilins from Acanthamoeba suggests that the ability of profilin to suppress cap- cells is dependent upon a property other than, or in addition to, its ability to bind actin [8].
  • Forms of RNA polymerase I prepared from growing or encysted Acanthamoeba are equal in the ability to transcribe poly(dl:dC) [9].
  • We describe the mechanical properties of a model system consisting of actin filaments and Acanthamoeba alpha-actinin, one of several actin crosslinking proteins found in amoeba and other cells [10].
  • Electron cryomicroscopy and three-dimensional reconstruction of Acanthamoeba castellanii and Saccharomyces cerevisiae Arp2/3 complexes bound to the WASp carboxy-terminal domain reveal asymmetric, oblate ellipsoids [11].

Chemical compound and disease context of Acanthamoeba


Biological context of Acanthamoeba


Anatomical context of Acanthamoeba


Associations of Acanthamoeba with chemical compounds

  • The actin-activated Mg(2+)-ATPase activities of Acanthamoeba myosins I are known to be maximally expressed only when a single threonine (myosin IA) or serine (myosins IB and IC) is phosphorylated by myosin I heavy chain kinase [26].
  • Identification of functional regions on the tail of Acanthamoeba myosin-II using recombinant fusion proteins. II. Assembly properties of tails with NH2- and COOH-terminal deletions [27].
  • Two Triton-insoluble fractions were isolated from Acanthamoeba castellanii [28].
  • Isolation and electrophoretic analysis of nucleoli, phenol-soluble nuclear proteins, and outer cyst walls from Acanthamoeba castellanii during encystation initiation [29].
  • Profilins bind to monomeric actin and also interact with ligands such as phosphoinositide 4,5-bisphosphate, the proline-rich protein VASP and a complex of four to six polypeptides identified in Acanthamoeba that includes two actin-related proteins [30].

Gene context of Acanthamoeba


Analytical, diagnostic and therapeutic context of Acanthamoeba


  1. The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches. Winter, D., Podtelejnikov, A.V., Mann, M., Li, R. Curr. Biol. (1997) [Pubmed]
  2. Effects of an isogenic Zn-metalloprotease-deficient mutant of Legionella pneumophila in a guinea-pig pneumonia model. Moffat, J.F., Edelstein, P.H., Regula, D.P., Cirillo, J.D., Tompkins, L.S. Mol. Microbiol. (1994) [Pubmed]
  3. Fulminant amebic meningoencephalitis due to Acanthamoeba. Grunnet, M.L., Cannon, G.H., Kushner, J.P. Neurology (1981) [Pubmed]
  4. Role of contact lens wear, bacterial flora, and mannose-induced pathogenic protease in the pathogenesis of amoebic keratitis. Alizadeh, H., Neelam, S., Hurt, M., Niederkorn, J.Y. Infect. Immun. (2005) [Pubmed]
  5. Treatment of Nocardia asteroides keratitis with polyhexamethylene biguanide. Lin, J.C., Ward, T.P., Belyea, D.A., McEvoy, P., Kramer, K.K. Ophthalmology (1997) [Pubmed]
  6. Defense mechanisms of IFN-gamma and LPS-primed murine microglia against Acanthamoeba castellanii infection. Benedetto, N., Rossano, F., Gorga, F., Folgore, A., Rao, M., Romano Carratelli, C. Int. Immunopharmacol. (2003) [Pubmed]
  7. chickadee encodes a profilin required for intercellular cytoplasm transport during Drosophila oogenesis. Cooley, L., Verheyen, E., Ayers, K. Cell (1992) [Pubmed]
  8. Evidence for a functional link between profilin and CAP in the yeast S. cerevisiae. Vojtek, A., Haarer, B., Field, J., Gerst, J., Pollard, T.D., Brown, S., Wigler, M. Cell (1991) [Pubmed]
  9. Regulation of eukaryotic ribosomal RNA transcription by RNA polymerase modification. Bateman, E., Paule, M.R. Cell (1986) [Pubmed]
  10. Dependence of the mechanical properties of actin/alpha-actinin gels on deformation rate. Sato, M., Schwarz, W.H., Pollard, T.D. Nature (1987) [Pubmed]
  11. Structure of Arp2/3 complex in its activated state and in actin filament branch junctions. Volkmann, N., Amann, K.J., Stoilova-McPhie, S., Egile, C., Winter, D.C., Hazelwood, L., Heuser, J.E., Li, R., Pollard, T.D., Hanein, D. Science (2001) [Pubmed]
  12. Amoebicidal efficiencies of various diamidines against two strains of Acanthamoeba polyphaga. Perrine, D., Chenu, J.P., Georges, P., Lancelot, J.C., Saturnino, C., Robba, M. Antimicrob. Agents Chemother. (1995) [Pubmed]
  13. Neuraminidase activity in acanthamoeba species trophozoites and cysts. Pellegrin, J.L., Ortega-Barria, E., Barza, M., Baum, J., Pereira, M.E. Invest. Ophthalmol. Vis. Sci. (1991) [Pubmed]
  14. Treatment of acanthamoeba keratitis with chlorhexidine. Kosrirukvongs, P., Wanachiwanawin, D., Visvesvara, G.S. Ophthalmology (1999) [Pubmed]
  15. Treatment of Acanthamoeba keratitis with polyhexamethylene biguanide. Larkin, D.F., Kilvington, S., Dart, J.K. Ophthalmology (1992) [Pubmed]
  16. Enhanced killing of Acanthamoeba cysts with a plant peroxidase-hydrogen peroxide-halide antimicrobial system. Hughes, R., Andrew, P.W., Kilvington, S. Appl. Environ. Microbiol. (2003) [Pubmed]
  17. Mechanism of action of Acanthamoeba profilin: demonstration of actin species specificity and regulation by micromolar concentrations of MgCl2. Tseng, P.C., Pollard, T.D. J. Cell Biol. (1982) [Pubmed]
  18. p21-activated kinase has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin I. Brzeska, H., Knaus, U.G., Wang, Z.Y., Bokoch, G.M., Korn, E.D. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  19. Yeast is unable to excise foreign intervening sequences from hybrid gene transcripts. Langford, C., Nellen, W., Niessing, J., Gallwitz, D. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  20. Amino acid sequence of a segment of the Acanthamoeba myosin II heavy chain containing all three regulatory phosphorylation sites. Côté, G.P., Robinson, E.A., Appella, E., Korn, E.D. J. Biol. Chem. (1984) [Pubmed]
  21. Amino acid sequence of the active site of Acanthamoeba myosin II. Atkinson, M.A., Robinson, E.A., Appella, E., Korn, E.D. J. Biol. Chem. (1986) [Pubmed]
  22. Bundling of actin filaments by alpha-actinin depends on its molecular length. Meyer, R.K., Aebi, U. J. Cell Biol. (1990) [Pubmed]
  23. Electron partitioning between the two branching quinol-oxidizing pathways in Acanthamoeba castellanii mitochondria during steady-state state 3 respiration. Jarmuszkiewicz, W., Sluse-Goffart, C.M., Hryniewiecka, L., Michejda, J., Sluse, F.E. J. Biol. Chem. (1998) [Pubmed]
  24. Tail chimeras of Dictyostelium myosin II support cytokinesis and other myosin II activities but not full development. Shu, S., Liu, X., Parent, C.A., Uyeda, T.Q., Korn, E.D. J. Cell. Sci. (2002) [Pubmed]
  25. An upstream promoter element of the Acanthamoeba castellanii TBP gene binds a DNA sequence specific transcription activating protein, TPBF. Liu, F., Bateman, E. Nucleic Acids Res. (1993) [Pubmed]
  26. Immunolocalization of myosin I heavy chain kinase in Acanthamoeba castellanii and binding of purified kinase to isolated plasma membranes. Kulesza-Lipka, D., Baines, I.C., Brzeska, H., Korn, E.D. J. Cell Biol. (1991) [Pubmed]
  27. Identification of functional regions on the tail of Acanthamoeba myosin-II using recombinant fusion proteins. II. Assembly properties of tails with NH2- and COOH-terminal deletions. Sinard, J.H., Rimm, D.L., Pollard, T.D. J. Cell Biol. (1990) [Pubmed]
  28. Isolation and partial characterization of a 110-kD dimer actin-binding protein. Ueno, T., Korn, E.D. J. Cell Biol. (1986) [Pubmed]
  29. Isolation and electrophoretic analysis of nucleoli, phenol-soluble nuclear proteins, and outer cyst walls from Acanthamoeba castellanii during encystation initiation. Rubin, R.W., Hill, M.C., Hepworth, P., Boehmer, J. J. Cell Biol. (1976) [Pubmed]
  30. Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function. Balasubramanian, M.K., Feoktistova, A., McCollum, D., Gould, K.L. EMBO J. (1996) [Pubmed]
  31. The EGF receptor is an actin-binding protein. den Hartigh, J.C., van Bergen en Henegouwen, P.M., Verkleij, A.J., Boonstra, J. J. Cell Biol. (1992) [Pubmed]
  32. Expression of a continuous open reading frame encoding subunits 1 and 2 of cytochrome c oxidase in the mitochondrial DNA of Acanthamoeba castellanii. Lonergan, K.M., Gray, M.W. J. Mol. Biol. (1996) [Pubmed]
  33. Characterization of renatured profilin purified by urea elution from poly-L-proline agarose columns. Kaiser, D.A., Goldschmidt-Clermont, P.J., Levine, B.A., Pollard, T.D. Cell Motil. Cytoskeleton (1989) [Pubmed]
  34. Identification and molecular characterization of a yeast myosin I. Goodson, H.V., Spudich, J.A. Cell Motil. Cytoskeleton (1995) [Pubmed]
  35. The interaction of Acanthamoeba spp. with activated macrophages and with macrophage cell lines. Marciano-Cabral, F., Toney, D.M. J. Eukaryot. Microbiol. (1998) [Pubmed]
  36. Structure, subunit topology, and actin-binding activity of the Arp2/3 complex from Acanthamoeba. Mullins, R.D., Stafford, W.F., Pollard, T.D. J. Cell Biol. (1997) [Pubmed]
  37. X-ray structures of isoforms of the actin-binding protein profilin that differ in their affinity for phosphatidylinositol phosphates. Fedorov, A.A., Magnus, K.A., Graupe, M.H., Lattman, E.E., Pollard, T.D., Almo, S.C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  38. Enhanced attachment of acanthamoeba to extended-wear silicone hydrogel contact lenses: a new risk factor for infection? Beattie, T.K., Tomlinson, A., McFadyen, A.K., Seal, D.V., Grimason, A.M. Ophthalmology (2003) [Pubmed]
  39. Antigens of selected Acanthamoeba species detected with monoclonal antibodies. Turner, M.L., Cockerell, E.J., Brereton, H.M., Badenoch, P.R., Tea, M., Coster, D.J., Williams, K.A. Int. J. Parasitol. (2005) [Pubmed]
  40. Molecular and functional characterization of type I signal peptidase from Legionella pneumophila. Lammertyn, E., Van Mellaert, L., Meyen, E., Lebeau, I., De Buck, E., Anné, J., Geukens, N. Microbiology (Reading, Engl.) (2004) [Pubmed]
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