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Gene Review

IDDM11  -  insulin-dependent diabetes mellitus 11

Homo sapiens

 
 
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Disease relevance of IDDM11

 

High impact information on IDDM11

  • This location overlaps with IDDM11 and includes SEL1L, a negative regulator of the Notch pathway that may control islet development [2].
  • A new susceptibility locus (IDDM11) has been localized to chromosome 14q24.3-q31 by detection of significant linkage to microsatellite D14S67, using both maximum likelihood methods (LODmax = 4.0 at Theta = 0.20) and affected sib pair (ASP) methods (P = 1 x 10(-5)) [1].
  • Grade-of-membership sibpair linkage analysis maps IDDM11 to chromosome 14q24.3-q31 [3].
  • No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility [4].
  • Using a linkage based approach which only detects highly significant susceptibility genes we have recently reported preliminary results which demonstrated that a marker located approximately 25 cM from the TSH receptor gene on chromosome 14q31 is linked to GD and in the same vicinity as the IDDM-11 locus [5].

References

  1. Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on human chromosome 14q24.3-q31. Field, L.L., Tobias, R., Thomson, G., Plon, S. Genomics (1996) [Pubmed]
  2. Genetic modifiers of the age at diagnosis of diabetes (MODY3) in carriers of hepatocyte nuclear factor-1alpha mutations map to chromosomes 5p15, 9q22, and 14q24. Kim, S.H., Ma, X., Klupa, T., Powers, C., Pezzolesi, M., Warram, J.H., Rich, S.S., Krolewski, A.S., Doria, A. Diabetes (2003) [Pubmed]
  3. Grade-of-membership sibpair linkage analysis maps IDDM11 to chromosome 14q24.3-q31. Corder, E.H., Woodbury, M.A., Manton, K.G., Field, L.L. Ann. Hum. Genet. (2001) [Pubmed]
  4. No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility. Pociot, F., Larsen, Z.M., Zavattari, P., Deidda, E., Nerup, J., Cattaneo, M., Chiaramonte, R., Comi, P., Sabbadini, M., Zollo, M., Biunno, I., Cucca, F. Diabetes Metab. Res. Rev. (2001) [Pubmed]
  5. The genetic susceptibility to Graves' disease. Tomer, Y., Davies, T.F. Baillieres Clin. Endocrinol. Metab. (1997) [Pubmed]
 
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