Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

CD300E - CD300e molecule

Homo sapiens

Synonyms: CD300 antigen-like family member E, CD300LE, CLM-2, CLM2, CMRF35-A5, ...

Aguilar, H. et al.

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High impact information on CD300E

Indeed, the interaction between IREM-2 and DAP-12 was confirmed in transfected COS-7 cells [1].
In vitro differentiation to macrophages or immature dendritic cells down-regulated IREM-2 expression [1].
On the basis of this information, we cloned a full length cDNA corresponding to a novel member of this family, termed immune receptor expressed by myeloid cells 2 (IREM-2) [1].

Anatomical context of CD300E

By generating specific Abs and using bone marrow and PBMCs, we observed that IREM-2 expression appeared to be restricted to mature hemopoietic cells of the monocytic and myeloid dendritic cell lineages [1].

References

Molecular characterization of a novel immune receptor restricted to the monocytic lineage. Aguilar, H., Alvarez-Errico, D., García-Montero, A.C., Orfao, A., Sayós, J., López-Botet, M. J. Immunol. (2004) [Pubmed]

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