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Gene Review:

TGM6 - transglutaminase 6

Homo sapiens

Synonyms: Protein-glutamine gamma-glutamyltransferase 6, SCA35, TG6, TGM3L, TGY, ...

Brumlik, M.J. et al., Goedert, M. et al., Wang, X.S. et al., Lu, G. et al., Jiang, Y. et al.

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High impact information on TGM6

A cDNA was cloned that encodes human stress-activated protein kinase-4 (SAPK4), a novel MAP kinase family member whose amino acid sequence is approximately 60% identical to that of the other three SAP kinases which contain a TGY motif in their activation domain [1].
Stress-activated mitogen-activated protein (MAP) kinase p38 mediates stress signaling in mammalian cells via threonine and tyrosine phosphorylation in its conserved TGY motif by upstream MAP kinase kinases (MKKs) [2].
The novel kinase, p38delta, has a nucleotide sequence encoding a protein of 365 amino acids with a putative TGY dual phosphorylation motif [3].
This gene is predicted to encode a 58kDa protein with a threonine, aspartic acid, tyrosine (TDY) activation loop, similar to parasite and plant mitogen activated protein kinases, but distinct from mammalian mitogen activated protein kinases (with threonine, glycine, tyrosine (TGY) motifs) [4].

Biological context of TGM6

It contains a TGY dual phosphorylation site, which is required for its kinase activity [5].

References

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. Goedert, M., Cuenda, A., Craxton, M., Jakes, R., Cohen, P. EMBO J. (1997) [Pubmed]
TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling. Lu, G., Kang, Y.J., Han, J., Herschman, H.R., Stefani, E., Wang, Y. J. Biol. Chem. (2006) [Pubmed]
Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase. Wang, X.S., Diener, K., Manthey, C.L., Wang, S., Rosenzweig, B., Bray, J., Delaney, J., Cole, C.N., Chan-Hui, P.Y., Mantlo, N., Lichenstein, H.S., Zukowski, M., Yao, Z. J. Biol. Chem. (1997) [Pubmed]
Identification of a novel mitogen-activated protein kinase in Toxoplasma gondii. Brumlik, M.J., Wei, S., Finstad, K., Nesbit, J., Hyman, L.E., Lacey, M., Burow, M.E., Curiel, T.J. Int. J. Parasitol. (2004) [Pubmed]
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). Jiang, Y., Chen, C., Li, Z., Guo, W., Gegner, J.A., Lin, S., Han, J. J. Biol. Chem. (1996) [Pubmed]

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TGM6	Bos taurus
TGM6	Canis lupus familiaris
LOC559691	Danio rerio
TGM6	Gallus gallus
Tgm6	Mus musculus
TGM6	Pan troglodytes
Tgm6	Rattus norvegicus
LOC101730677	Xenopus (Silurana) tropicalis

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