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Gene Review

TGM6  -  transglutaminase 6

Homo sapiens

Synonyms: Protein-glutamine gamma-glutamyltransferase 6, SCA35, TG6, TGM3L, TGY, ...
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High impact information on TGM6


Biological context of TGM6

  • It contains a TGY dual phosphorylation site, which is required for its kinase activity [5].


  1. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. Goedert, M., Cuenda, A., Craxton, M., Jakes, R., Cohen, P. EMBO J. (1997) [Pubmed]
  2. TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling. Lu, G., Kang, Y.J., Han, J., Herschman, H.R., Stefani, E., Wang, Y. J. Biol. Chem. (2006) [Pubmed]
  3. Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase. Wang, X.S., Diener, K., Manthey, C.L., Wang, S., Rosenzweig, B., Bray, J., Delaney, J., Cole, C.N., Chan-Hui, P.Y., Mantlo, N., Lichenstein, H.S., Zukowski, M., Yao, Z. J. Biol. Chem. (1997) [Pubmed]
  4. Identification of a novel mitogen-activated protein kinase in Toxoplasma gondii. Brumlik, M.J., Wei, S., Finstad, K., Nesbit, J., Hyman, L.E., Lacey, M., Burow, M.E., Curiel, T.J. Int. J. Parasitol. (2004) [Pubmed]
  5. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). Jiang, Y., Chen, C., Li, Z., Guo, W., Gegner, J.A., Lin, S., Han, J. J. Biol. Chem. (1996) [Pubmed]
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