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Gene Review

MAPK13  -  mitogen-activated protein kinase 13

Homo sapiens

Synonyms: MAP kinase 13, MAP kinase p38 delta, MAPK 13, MAPK-13, Mitogen-activated protein kinase 13, ...
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Disease relevance of MAPK13


High impact information on MAPK13


Biological context of MAPK13


Anatomical context of MAPK13


Associations of MAPK13 with chemical compounds

  • Consistent with a role for FHFs as signaling molecules, FHF2 isolated from rat brain is serine/threonine-phosphorylated, and FHF can serve as a substrate for p38delta in vitro [9].
  • However, unlike the other p38 isoforms, the kinase activity of p38delta is not blocked by the pyridinyl imidazole, 4-(4-fluorophenyl)-2-2(4-hydroxyphenyl)-5-(4-pyridyl)-imidazole (identicalto SB202190). p38delta can be activated by MKK3 and MKK6, known activators of the other isoforms [10].
  • Mutation of T106 to glutamine, the residue present at the corresponding position in ERK-2, or methionine, the corresponding residue in p38gamma, p38delta, and the JNKs, rendered all five inhibitors ineffective [11].
  • Phosphorylation by PKA and SAPK4/p38delta abolished the ability of tau to promote microtubule assembly, but failed to influence significantly the heparin-induced assembly of tau into filaments [12].

Physical interactions of MAPK13

  • FHF2 also binds weakly to IB2(Delta1-436) and can thereby increase p38delta interaction with IB2(Delta1-436) [9].

Enzymatic interactions of MAPK13

  • In transient expression studies, we found that in addition to different stimuli osmotic stress activates p38 delta to phosphorylate stathmin [13].

Regulatory relationships of MAPK13

  • Thus, p38 delta may directly suppress ERK1/2 activity [14].
  • We asked whether not only intact but also altered L1s can exert biological activities by transfecting RA synovial fibroblasts (SF) with either retrotransposition-competent or incompetent L1s and examined their capacity to induce p38delta [15].

Other interactions of MAPK13


Analytical, diagnostic and therapeutic context of MAPK13


  1. p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity. Pramanik, R., Qi, X., Borowicz, S., Choubey, D., Schultz, R.M., Han, J., Chen, G. J. Biol. Chem. (2003) [Pubmed]
  2. Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils. Nick, J.A., Avdi, N.J., Young, S.K., Lehman, L.A., McDonald, P.P., Frasch, S.C., Billstrom, M.A., Henson, P.M., Johnson, G.L., Worthen, G.S. J. Clin. Invest. (1999) [Pubmed]
  3. A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta. Knebel, A., Morrice, N., Cohen, P. EMBO J. (2001) [Pubmed]
  4. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. Goedert, M., Cuenda, A., Craxton, M., Jakes, R., Cohen, P. EMBO J. (1997) [Pubmed]
  5. Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways. Knebel, A., Haydon, C.E., Morrice, N., Cohen, P. Biochem. J. (2002) [Pubmed]
  6. Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex. Efimova, T., Broome, A.M., Eckert, R.L. Mol. Cell. Biol. (2004) [Pubmed]
  7. Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase. Wang, X.S., Diener, K., Manthey, C.L., Wang, S., Rosenzweig, B., Bray, J., Delaney, J., Cole, C.N., Chan-Hui, P.Y., Mantlo, N., Lichenstein, H.S., Zukowski, M., Yao, Z. J. Biol. Chem. (1997) [Pubmed]
  8. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Kumar, S., McDonnell, P.C., Gum, R.J., Hand, A.T., Lee, J.C., Young, P.R. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  9. Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase. Schoorlemmer, J., Goldfarb, M. J. Biol. Chem. (2002) [Pubmed]
  10. Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta. Jiang, Y., Gram, H., Zhao, M., New, L., Gu, J., Feng, L., Di Padova, F., Ulevitch, R.J., Han, J. J. Biol. Chem. (1997) [Pubmed]
  11. Molecular basis for p38 protein kinase inhibitor specificity. Lisnock, J., Tebben, A., Frantz, B., O'Neill, E.A., Croft, G., O'Keefe, S.J., Li, B., Hacker, C., de Laszlo, S., Smith, A., Libby, B., Liverton, N., Hermes, J., LoGrasso, P. Biochemistry (1998) [Pubmed]
  12. Sequential phosphorylation of tau protein by cAMP-dependent protein kinase and SAPK4/p38delta or JNK2 in the presence of heparin generates the AT100 epitope. Yoshida, H., Goedert, M. J. Neurochem. (2006) [Pubmed]
  13. Identification of stathmin as a novel substrate for p38 delta. Parker, C.G., Hunt, J., Diener, K., McGinley, M., Soriano, B., Keesler, G.A., Bray, J., Yao, Z., Wang, X.S., Kohno, T., Lichenstein, H.S. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  14. A regulatory role for p38 delta MAPK in keratinocyte differentiation. Evidence for p38 delta-ERK1/2 complex formation. Efimova, T., Broome, A.M., Eckert, R.L. J. Biol. Chem. (2003) [Pubmed]
  15. The L1 retroelement-related p40 protein induces p38delta MAP kinase. Kuchen, S., Seemayer, C.A., Rethage, J., von Knoch, R., Kuenzler, P., Beat, A.M., Gay, R.E., Gay, S., Neidhart, M. Autoimmunity (2004) [Pubmed]
  16. Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines. Hu, M.C., Wang, Y.P., Mikhail, A., Qiu, W.R., Tan, T.H. J. Biol. Chem. (1999) [Pubmed]
  17. Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly. Feijoo, C., Campbell, D.G., Jakes, R., Goedert, M., Cuenda, A. J. Cell. Sci. (2005) [Pubmed]
  18. Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages. Hale, K.K., Trollinger, D., Rihanek, M., Manthey, C.L. J. Immunol. (1999) [Pubmed]
  19. Phosphorylation of cytosolic phospholipase A2 in platelets is mediated by multiple stress-activated protein kinase pathways. Börsch-Haubold, A.G., Ghomashchi, F., Pasquet, S., Goedert, M., Cohen, P., Gelb, M.H., Watson, S.P. Eur. J. Biochem. (1999) [Pubmed]
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