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Gene Review

GPR148  -  G protein-coupled receptor 148

Homo sapiens

Synonyms: BTR, Brain and testis restricted GPCR, G-protein coupled receptor PGR6, PGR6
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Disease relevance of GPR148

  • Forty-seven percent of BTR (8/17) recurred at the site of original metastasis; 35% (6/17) recurred at both original [corrected] and distant sites in the brain, and 18% (3/17) recurred at distant only [corrected] brain sites [1].
  • In the univariate analysis, several factors, including number of brain metastases, treatment for brain metastasis with brain tumor resection (BTR) or whole brain radiation therapy (WBRT), and chemotherapy (C/T) after brain metastasis were found to have significant influence on the survival [2].

High impact information on GPR148


Analytical, diagnostic and therapeutic context of GPR148


  1. Risk of symptomatic brain tumor recurrence and neurologic deficit after radiosurgery alone in patients with newly diagnosed brain metastases: results and implications. Regine, W.F., Huhn, J.L., Patchell, R.A., St Clair, W.H., Strottmann, J., Meigooni, A., Sanders, M., Young, A.B. Int. J. Radiat. Oncol. Biol. Phys. (2002) [Pubmed]
  2. Late survival of non-small cell lung cancer patients with brain metastases. Influence of treatment. Chang, D.B., Yang, P.C., Luh, K.T., Kuo, S.H., Hong, R.L., Lee, L.N. Chest (1992) [Pubmed]
  3. Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Gloriam, D.E., Schiöth, H.B., Fredriksson, R. Biochim. Biophys. Acta (2005) [Pubmed]
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