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Gene Review:

GPR148 - G protein-coupled receptor 148

Homo sapiens

Synonyms: BTR, Brain and testis restricted GPCR, G-protein coupled receptor PGR6, PGR6

Regine, W.F. et al., Chang, D.B. et al., Gloriam, D.E. et al.

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Disease relevance of GPR148

Forty-seven percent of BTR (8/17) recurred at the site of original metastasis; 35% (6/17) recurred at both original [corrected] and distant sites in the brain, and 18% (3/17) recurred at distant only [corrected] brain sites [1].
In the univariate analysis, several factors, including number of brain metastases, treatment for brain metastasis with brain tumor resection (BTR) or whole brain radiation therapy (WBRT), and chemotherapy (C/T) after brain metastasis were found to have significant influence on the survival [2].

High impact information on GPR148

GPR162 and GPR139 are remarkably well conserved while GPR148 seems to be evolving rapidly [3].

Analytical, diagnostic and therapeutic context of GPR148

PURPOSE: A single-institution experience using primary stereotactic radiosurgery (SRS) alone in the management of newly diagnosed brain metastases was analyzed to identify the risk of symptomatic brain tumor recurrence (BTR) and neurologic deficit associated with such a treatment strategy [1].

References

Risk of symptomatic brain tumor recurrence and neurologic deficit after radiosurgery alone in patients with newly diagnosed brain metastases: results and implications. Regine, W.F., Huhn, J.L., Patchell, R.A., St Clair, W.H., Strottmann, J., Meigooni, A., Sanders, M., Young, A.B. Int. J. Radiat. Oncol. Biol. Phys. (2002) [Pubmed]
Late survival of non-small cell lung cancer patients with brain metastases. Influence of treatment. Chang, D.B., Yang, P.C., Luh, K.T., Kuo, S.H., Hong, R.L., Lee, L.N. Chest (1992) [Pubmed]
Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Gloriam, D.E., Schiöth, H.B., Fredriksson, R. Biochim. Biophys. Acta (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

GPR148	Canis lupus familiaris
LOC101885431	Danio rerio
GPR148	Macaca mulatta
GPR148	Pan troglodytes

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