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GPR139  -  G protein-coupled receptor 139

Homo sapiens

Synonyms: G(q)-coupled orphan receptor GPRg1, G-protein-coupled receptor PGR3, GPRG1, GPRg1, PGR3
 
 
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High impact information on GPR139

 

Anatomical context of GPR139

  • GPR138 and GPR139 share identities with an odorant-like gene derived from human erythroid cells [3].
  • These findings suggest that GPRg1 is a candidate receptor for novel physiologically bioactive substrates and that it plays important roles in the central nervous system [2].
 

Other interactions of GPR139

  • GPR162 and GPR139 are remarkably well conserved while GPR148 seems to be evolving rapidly [4].
  • GPR139 mRNA was predominantly expressed in specific areas of human and mouse brains, whereas GPR142 mRNA showed a more ubiquitous expression both in the brain and in various peripheral glands and organs [1].
 

Analytical, diagnostic and therapeutic context of GPR139

  • Quantitative PCR analysis revealed that GPRg1 transcripts are expressed almost exclusively in the brain [2].
  • Of the remaining five RCTs, four were included in the meta-analysis (Buttram 1969; Cullberg 1972; GPRG 1968; Nakano 1971) [5].

References

  1. Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development. Süsens, U., Hermans-Borgmeyer, I., Urny, J., Schaller, H.C. Neuropharmacology (2006) [Pubmed]
  2. Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system. Matsuo, A., Matsumoto, S., Nagano, M., Masumoto, K.H., Takasaki, J., Matsumoto, M., Kobori, M., Katoh, M., Shigeyoshi, Y. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  3. Novel human G-protein-coupled receptors. Vanti, W.B., Nguyen, T., Cheng, R., Lynch, K.R., George, S.R., O'Dowd, B.F. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  4. Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Gloriam, D.E., Schiöth, H.B., Fredriksson, R. Biochim. Biophys. Acta (2005) [Pubmed]
  5. Combined oral contraceptive pill (OCP) as treatment for primary dysmenorrhoea. Proctor, M.L., Roberts, H., Farquhar, C.M. Cochrane database of systematic reviews (Online) (2001) [Pubmed]
 
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