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MeSH Review


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Disease relevance of Radiosurgery


High impact information on Radiosurgery

  • At day 60, patients with at least stable disease received hyperfractionated (n = 9) or conventional external-beam radiotherapy (n = 2) preceded by local radioactive iodine 125 implantation (n = 2) or radiosurgery (n = 1) [6].
  • Withdrawal of somatostatin agonists at the time of radiosurgery had no incidence on the outcome [7].
  • We also showed that further gains in therapeutic outcome could be achieved by combining TNF alpha-enhanced SGT with gamma-knife radiosurgery (GKR) [8].
  • Radiosurgery has been recently utilized in the treatment of epilepsy with preliminary promising results [9].
  • To evaluate the hyperacute effect of high-dose irradiation on tumor glucose metabolism in vivo, we measured 2-[18F]fluoro-2-deoxy-D-glucose (FDG) tumor uptake before and immediately after stereotactic radiosurgery [1].

Chemical compound and disease context of Radiosurgery


Biological context of Radiosurgery


Anatomical context of Radiosurgery


Associations of Radiosurgery with chemical compounds

  • All patients underwent clinical and audiologic evaluations varying from 6 to 48 months (mean, 20 months) after stereotactic radiosurgery performed with use of the 201 source cobalt 60 gamma unit [22].
  • CONCLUSIONS: The 21-aminosteroid U-74389G exhibits a radioprotectant effect on normal brain tissue, but does not appear to protect the tumor in an in vivo rat radiosurgery model [3].
  • Marimastat was administered after radiosurgery to restrict regional tumor progression [10].
  • PURPOSE: The relative efficacy of Gamma Knife, Linac, and Proton treatment modalities for stereotactic radiosurgery (SRS) was investigated on the basis of normal tissue complication probability (NTCP) and tumor control probability (TCP), calculated for representative test cases [23].
  • The purpose of the present study was to investigate the role of cytotoxic drugs, such as BCNU and carboplatin, in combination with a single high dose of radiosurgery on the tumor control rates of 9L tumors in the rat brain [24].

Gene context of Radiosurgery


Analytical, diagnostic and therapeutic context of Radiosurgery


  1. Hyperacute changes in glucose metabolism of brain tumors after stereotactic radiosurgery: a PET study. Maruyama, I., Sadato, N., Waki, A., Tsuchida, T., Yoshida, M., Fujibayashi, Y., Ishii, Y., Kubota, T., Yonekura, Y. J. Nucl. Med. (1999) [Pubmed]
  2. Dosimetric results from a feasibility study of a novel radiosurgical source for irradiation of intracranial metastases. Douglas, R.M., Beatty, J., Gall, K., Valenzuela, R.F., Biggs, P., Okunieff, P., Pardo, F.S. Int. J. Radiat. Oncol. Biol. Phys. (1996) [Pubmed]
  3. Beneficial effects of the radioprotectant 21-aminosteroid U-74389G in a radiosurgery rat malignant glioma model. Kondziolka, D., Mori, Y., Martinez, A.J., McLaughlin, M.R., Flickinger, J.C., Lunsford, L.D. Int. J. Radiat. Oncol. Biol. Phys. (1999) [Pubmed]
  4. Control of epilepsy associated with cerebral arteriovenous malformations after radiosurgery. Kurita, H., Kawamoto, S., Suzuki, I., Sasaki, T., Tago, M., Terahara, A., Kirino, T. J. Neurol. Neurosurg. Psychiatr. (1998) [Pubmed]
  5. Factors predicting local tumor control after gamma knife stereotactic radiosurgery for benign intracranial meningiomas. DiBiase, S.J., Kwok, Y., Yovino, S., Arena, C., Naqvi, S., Temple, R., Regine, W.F., Amin, P., Guo, C., Chin, L.S. Int. J. Radiat. Oncol. Biol. Phys. (2004) [Pubmed]
  6. High-dose chemotherapy and autologous bone marrow rescue followed by interstitial and external-beam radiotherapy in newly diagnosed pediatric malignant gliomas. Heideman, R.L., Douglass, E.C., Krance, R.A., Fontanesi, J., Langston, J.A., Sanford, R.A., Kovnar, E.H., Ochs, J., Kuttesch, J., Jenkins, J.J. J. Clin. Oncol. (1993) [Pubmed]
  7. Outcome of gamma knife radiosurgery in 82 patients with acromegaly: correlation with initial hypersecretion. Castinetti, F., Taieb, D., Kuhn, J.M., Chanson, P., Tamura, M., Jaquet, P., Conte-Devolx, B., Régis, J., Dufour, H., Brue, T. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  8. Treatment of rat gliosarcoma brain tumors by HSV-based multigene therapy combined with radiosurgery. Niranjan, A., Wolfe, D., Tamura, M., Soares, M.K., Krisky, D.M., Lunsford, L.D., Li, S., Fellows-Mayle, W., DeLuca, N.A., Cohen, J.B., Glorioso, J.C. Mol. Ther. (2003) [Pubmed]
  9. Emerging surgical and radiotherapeutic techniques for treating epilepsy. Cohen-Gadol, A.A., Stoffman, M.R., Spencer, D.D. Curr. Opin. Neurol. (2003) [Pubmed]
  10. Phase II study of high central dose Gamma Knife radiosurgery and marimastat in patients with recurrent malignant glioma. Larson, D.A., Prados, M., Lamborn, K.R., Smith, V., Sneed, P.K., Chang, S., Nicholas, K.M., Wara, W.M., Devriendt, D., Kunwar, S., Berger, M., McDermott, M.W. Int. J. Radiat. Oncol. Biol. Phys. (2002) [Pubmed]
  11. Stereotactic radiosurgery with the cobalt-60 gamma unit in the treatment of growth hormone-producing pituitary tumors. Thorén, M., Rähn, T., Guo, W.Y., Werner, S. Neurosurgery (1991) [Pubmed]
  12. Effects of stereotactic radiosurgery on an animal model of hippocampal epilepsy. Mori, Y., Kondziolka, D., Balzer, J., Fellows, W., Flickinger, J.C., Lunsford, L.D., Thulborn, K.R. Neurosurgery (2000) [Pubmed]
  13. Current radiosurgery practice: results of an ASTRO survey. Task Force on Stereotactic Radiosurgery, American Society for Therapeutic Radiology and Oncology. Larson, D.A., Bova, F., Eisert, D., Kline, R., Loeffler, J., Lutz, W., Mehta, M., Palta, J., Schewe, K., Schultz, C. Int. J. Radiat. Oncol. Biol. Phys. (1994) [Pubmed]
  14. Department of Neurosurgery, Karolinska Institute: 60 years. Lindquist, C., Kihlström, L. Neurosurgery (1996) [Pubmed]
  15. Acute effects of stereotactic radiosurgery on the kinetics of glucose metabolism in metastatic brain tumors: FDG PET study. Yamamoto, T., Nishizawa, S., Maruyama, I., Yoshida, M., Tsuchida, T., Waki, A., Fujibayashi, Y., Kubota, T., Yonekura, Y., Itoh, H. Annals of nuclear medicine. (2001) [Pubmed]
  16. Radiobiologic models for radiosurgery. Altschuler, E., Lunsford, L.D., Kondziolka, D., Wu, A., Maitz, A.H., Sclabassi, R., Martinez, A.J., Flickinger, J.C. Neurosurg. Clin. N. Am. (1992) [Pubmed]
  17. Failure of low-dose radiosurgery to control temporal lobe epilepsy. Kawai, K., Suzuki, I., Kurita, H., Shin, M., Arai, N., Kirino, T. J. Neurosurg. (2001) [Pubmed]
  18. Time-dependent astroglial changes after gamma knife radiosurgery in the rat forebrain. Yang, T., Wu, S.L., Liang, J.C., Rao, Z.R., Ju, G. Neurosurgery (2000) [Pubmed]
  19. The Leksell gamma knife Model U versus Model C: a quantitative comparison of radiosurgical treatment parameters. Kuo, J.S., Yu, C., Giannotta, S.L., Petrovich, Z., Apuzzo, M.L. Neurosurgery (2004) [Pubmed]
  20. The prevention of radiosurgery-induced nausea and vomiting by ondansetron: evidence of a direct effect on the central nervous system chemoreceptor trigger zone. Bodis, S., Alexander, E., Kooy, H., Loeffler, J.S. Surgical neurology. (1994) [Pubmed]
  21. Radiosurgery for cranial base chordomas and chondrosarcomas. Krishnan, S., Foote, R.L., Brown, P.D., Pollock, B.E., Link, M.J., Garces, Y.I. Neurosurgery (2005) [Pubmed]
  22. Cranial nerve preservation after stereotactic radiosurgery for small acoustic tumors. Ogunrinde, O.K., Lunsford, L.D., Flickinger, J.C., Kondziolka, D.S. Arch. Neurol. (1995) [Pubmed]
  23. Comparison of radiosurgery treatment modalities based on complication and control probabilities. Smith, V., Verhey, L., Serago, C.F. Int. J. Radiat. Oncol. Biol. Phys. (1998) [Pubmed]
  24. Increased tumor cures using combined radiosurgery and BCNU in the treatment of 9l glioma in the rat brain. Khil, M.S., Kolozsvary, A., Apple, M., Kim, J.H. Int. J. Radiat. Oncol. Biol. Phys. (2000) [Pubmed]
  25. Current status and future opportunities for controlling acromegaly. Melmed, S., Vance, M.L., Barkan, A.L., Bengtsson, B.A., Kleinberg, D., Klibanski, A., Trainer, P.J. Pituitary (2002) [Pubmed]
  26. Intracranial vascular malformations: imaging of charged-particle radiosurgery. Part II. Complications. Marks, M.P., Delapaz, R.L., Fabrikant, J.I., Frankel, K.A., Phillips, M.H., Levy, R.P., Enzmann, D.R. Radiology. (1988) [Pubmed]
  27. Linear accelerator-based stereotactic radiosurgery for limited, locally persistent, and recurrent nasopharyngeal carcinoma: efficacy and complications. Chua, D.T., Sham, J.S., Kwong, P.W., Hung, K.N., Leung, L.H. Int. J. Radiat. Oncol. Biol. Phys. (2003) [Pubmed]
  28. Targeted intra-operative radiotherapy (Targit): an innovative method of treatment for early breast cancer. Vaidya, J.S., Baum, M., Tobias, J.S., D'Souza, D.P., Naidu, S.V., Morgan, S., Metaxas, M., Harte, K.J., Sliski, A.P., Thomson, E. Ann. Oncol. (2001) [Pubmed]
  29. Patterns of patient movement during frameless image-guided radiosurgery. Murphy, M.J., Chang, S.D., Gibbs, I.C., Le, Q.T., Hai, J., Kim, D., Martin, D.P., Adler, J.R. Int. J. Radiat. Oncol. Biol. Phys. (2003) [Pubmed]
  30. Vestibular schwannoma management. Part I. Failed microsurgery and the role of delayed stereotactic radiosurgery. Pollock, B.E., Lunsford, L.D., Flickinger, J.C., Clyde, B.L., Kondziolka, D. J. Neurosurg. (1998) [Pubmed]
  31. Gamma knife surgery for the treatment of intracranial metastases from breast cancer. Goyal, S., Prasad, D., Harrell, F., Matsumoto, J., Rich, T., Steiner, L. J. Neurosurg. (2005) [Pubmed]
  32. A prospective cost-effectiveness study of trigeminal neuralgia surgery. Pollock, B.E., Ecker, R.D. The Clinical journal of pain. (2005) [Pubmed]
  33. Add-on gabapentin for refractory seizures in patients with brain tumours. Perry, J.R., Sawka, C. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. (1996) [Pubmed]
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