Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

APOC4 - apolipoprotein C-IV

Homo sapiens

Synonyms: APO-CIV, APOC-IV, Apo-CIV, ApoC-IV, Apolipoprotein C-IV, ...

Kamboh, M.I. et al., Allan, C.M. et al., Kim, E. et al.

Kamboh, Hamman, Aston,

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Disease relevance of APOC4

Transient transfection of ApoC-IV cDNA into a human hepatoma cell line was able to trigger moderate lipid accumulation [1].

High impact information on APOC4

In this study we have assessed the presence of genetic variation in all three exons of APOC4 and their flanking intronic sequence by SSCP and DNA sequencing [2].
To our knowledge, the extent and nature of APOC4 genetic variation and its role in lipid metabolism are unknown [2].
Significant pairwise linkage disequilibrium was observed between five of the ten APOC4 pairs, including nt [2].
Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus [3].
The promoter of the APOC4 gene lacks a typical TATA box, consistent with an apparent heterogeneity in transcription start sites [3].

References

Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis. Kim, E., Li, K., Lieu, C., Tong, S., Kawai, S., Fukutomi, T., Zhou, Y., Wands, J., Li, J. J. Hepatol. (2008) [Pubmed]
DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid profile. Kamboh, M.I., Aston, C.E., Hamman, R.F. Atherosclerosis (2000) [Pubmed]
Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus. Allan, C.M., Walker, D., Segrest, J.P., Taylor, J.M. Genomics (1995) [Pubmed]

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