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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Rab6  -  CG6601 gene product from transcript CG6601-RB

Drosophila melanogaster

Synonyms: 136/6, AAF53168, CG6601, DRab6, Dm Rab6, ...
 
 
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Disease relevance of Rab6

  • These results establish that rhodopsin is transported via a Rab6 regulated pathway and that defects in trafficking pathways lead to retinal degeneration [1].
 

High impact information on Rab6

  • Our studies show, contrary to yeast, that the Drosophila homologue of rab6 is an essential gene [2].
  • Only the mechanosensory bristles on the head, notum, and scutellum are affected by warthog mutations [2].
  • Rab6 is a GTP binding protein that regulates vesicular trafficking within the Golgi and post-Golgi compartments [1].
  • We overexpressed wild-type, a GTPase defective (Q71L), and a guanine nucleotide binding defective (N125I) Rab6 protein in Drosophila photoreceptors to assess the in vivo role of Rab6 in the trafficking of rhodopsin and other proteins [1].
 

Physical interactions of Rab6

References

  1. Rab6 regulation of rhodopsin transport in Drosophila. Shetty, K.M., Kurada, P., O'Tousa, J.E. J. Biol. Chem. (1998) [Pubmed]
  2. The developmental role of warthog, the notch modifier encoding Drab6. Purcell, K., Artavanis-Tsakonas, S. J. Cell Biol. (1999) [Pubmed]
  3. Rab6 mediates membrane organization and determinant localization during Drosophila oogenesis. Coutelis, J.B., Ephrussi, A. Development (2007) [Pubmed]
  4. Rab6 and the secretory pathway affect oocyte polarity in Drosophila. Januschke, J., Nicolas, E., Compagnon, J., Formstecher, E., Goud, B., Guichet, A. Development (2007) [Pubmed]
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