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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

IFNW1  -  interferon, omega 1

Homo sapiens

Synonyms: Interferon alpha-II-1, Interferon omega-1
 
 
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High impact information on IFNW1

  • The data presented here indicate that allelic loss from 9p21-p22 is a common occurrence in MM and further delineate the location of a putative 9p tumor suppressor gene(s) to a region between IFNA/IFNW and D9S171 [1].
  • Homozygous losses (10 cell lines; 43%) occurred most often at the D9S171 and IFNA/IFNW loci [1].
  • Twenty-two strong SARs mapped to the flanking regions of 13 interferon (IFNA) alpha genes; 2 strong SARs mapped to one interferon omega (IFNW) gene; 2 strong SARs mapped to one interferon alpha pseudogene (IFNAP); and 3 strong SARs mapped to two interferon omega pseudogenes (IFNWP) [2].
  • This map contains 26 interferon (IFN) genes and pseudogenes, and it accounts for all, except one, of the IFN sequences previously reported by other authors, plus a new IFNW pseudogene [3].
  • These partial deletions allowed us to determine the order of some genes or groups of genes within the IFNA/IFNW gene cluster [4].
 

Biological context of IFNW1

  • The interferons alpha, beta, and w (IFNA, IFNB, IFNW), are a family of genes that have been mapped on the short arm of chromosome 9 (9p21-22) [5].

References

  1. Homozygous deletions within 9p21-p22 identify a small critical region of chromosomal loss in human malignant mesotheliomas. Cheng, J.Q., Jhanwar, S.C., Lu, Y.Y., Testa, J.R. Cancer Res. (1993) [Pubmed]
  2. Scaffold-associated regions in the human type I interferon gene cluster on the short arm of chromosome 9. Strissel, P.L., Dann, H.A., Pomykala, H.M., Diaz, M.O., Rowley, J.D., Olopade, O.I. Genomics (1998) [Pubmed]
  3. Structure of the human type-I interferon gene cluster determined from a YAC clone contig. Díaz, M.O., Pomykala, H.M., Bohlander, S.K., Maltepe, E., Malik, K., Brownstein, B., Olopade, O.I. Genomics (1994) [Pubmed]
  4. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. Olopade, O.I., Bohlander, S.K., Pomykala, H., Maltepe, E., Van Melle, E., Le Beau, M.M., Diaz, M.O. Genomics (1992) [Pubmed]
  5. Molecular study of the interferon genes in chronic myeloid leukemia. Larripa, I., Giere, I., Slavutsky, I., Diaz, M. Leuk. Res. (1995) [Pubmed]
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