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Gene Review:

IFNW1 - interferon, omega 1

Bos taurus

Imakawa, K. et al., Iannuzzi, L. et al., Hansen, T.R. et al., Liu, L. et al.

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High impact information on IFNW1

The genes for the trophoblast interferons and the related interferon-alpha II possess distinct 5'-promoter and 3'-flanking sequences [1].
Its entire sequence was 85% identical to that of a cDNA for the immunologically related ovine trophoblast protein-1 (oTP-1) and about 79% identical to that for a bovine interferon-alpha II (IFN alpha II) [2].
The giraffe IFNT gene possesses the highly conserved promoter region that distinguishes IFNT from IFNW [3].
The extensive G- and R-banding homology observed between cattle chromosome 8 and river buffalo chromosome arm 3q supports the conserved chromosomal location of the IFNW and IFNT genes in these two species [4].

Analytical, diagnostic and therapeutic context of IFNW1

Molecular cloning and characterization of complementary deoxyribonucleic acids corresponding to bovine trophoblast protein-1: a comparison with ovine trophoblast protein-1 and bovine interferon-alpha II [2].

References

The genes for the trophoblast interferons and the related interferon-alpha II possess distinct 5'-promoter and 3'-flanking sequences. Hansen, T.R., Leaman, D.W., Cross, J.C., Mathialagan, N., Bixby, J.A., Roberts, R.M. J. Biol. Chem. (1991) [Pubmed]
Molecular cloning and characterization of complementary deoxyribonucleic acids corresponding to bovine trophoblast protein-1: a comparison with ovine trophoblast protein-1 and bovine interferon-alpha II. Imakawa, K., Hansen, T.R., Malathy, P.V., Anthony, R.V., Polites, H.G., Marotti, K.R., Roberts, R.M. Mol. Endocrinol. (1989) [Pubmed]
The interferon-tau genes of the giraffe, a nonbovid species. Liu, L., Leaman, D.W., Roberts, R.M. J. Interferon Cytokine Res. (1996) [Pubmed]
Chromosomal localization of omega and trophoblast interferon genes in cattle and river buffalo by sequential R-banding and fluorescent in situ hybridization. Iannuzzi, L., Gallagher, D.S., Ryan, A.M., Di Meo, G.P., Womack, J.E. Cytogenet. Cell Genet. (1993) [Pubmed]

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