Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

TBX10 - T-box 10

Homo sapiens

Synonyms: T-box protein 10, T-box transcription factor TBX10, TBX13, TBX7

Bush, J.O. et al., Law, D.J. et al.

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High impact information on TBX10

TBX10, a member of the Tbx1-subfamily of conserved developmental genes, is located at human chromosome 11q13 and proximal mouse chromosome 19 [1].
The human TBX10 gene was previously identified from a genomic DNA sequence containing a partial open reading frame and was mapped to Chromosome 11q13, a chromosomal region associated with multiple inherited developmental disorders [2].
We have characterized the developmental expression patterns of Tbx10 during mouse embryogenesis by using in situ hybridization analyses [2].
Our results show that Tbx10 mRNA expression is highly restricted and exhibits a unique spatio-temporal pattern during hindbrain development [2].

Analytical, diagnostic and therapeutic context of TBX10

Sequence analysis of cDNA clones and reverse transcription-polymerase chain reaction products revealed that the previously predicted TBX10 open reading frame (GenBank accession number AH006177) was incorrect [2].

References

TBX10, a member of the Tbx1-subfamily of conserved developmental genes, is located at human chromosome 11q13 and proximal mouse chromosome 19. Law, D.J., Garvey, N., Agulnik, S.I., Perlroth, V., Hahn, O.M., Rhinehart, R.E., Gebuhr, T.C., Silver, L.M. Mamm. Genome (1998) [Pubmed]
The T-box gene Tbx10 exhibits a uniquely restricted expression pattern during mouse embryogenesis. Bush, J.O., Maltby, K.M., Cho, E.S., Jiang, R. Gene Expr. Patterns (2003) [Pubmed]

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