High impact information on Acyp

• The acylphosphatases from Sulfolobus solfataricus and Drosophila melanogaster (Sso AcP and AcPDro2) were previously shown to form amyloid-like aggregates without the need to unfold initially [1].
• The inhibitory effect of the 5' untranslated region of muscle acylphosphatase mRNA on protein expression is relieved during cell differentiation [2].
• An open reading frame encoding a putative acylphosphatase was found in Drosophila melanogaster [3].
• In addition, hybridization of clone AhT/VD16 to water strider (Gerris argentatus) genomic DNA, and sequence similarities to mammalian acylphosphatase, suggest that it represents an evolutionarily conserved sequence [4].
• It is involved in the hydrolysis of carboxyl-phosphate bonds in several acylphosphate substrates, such as carbamoylphosphate and 1,3-biphosphoglycerate; however, a consensus on acylphosphatase action in vivo has not yet been reached [5].

Other interactions of Acyp

• Analysis of the Drosophila melanogaster EST database led to the characterization of a novel acylphosphatase (AcPDro2) [6].

Analytical, diagnostic and therapeutic context of Acyp

• The structural and catalytic importance of the 15-21 and 42-45 loop residues of the acylphosphatase muscular isoenzyme has been investigated by oligonucleotide-directed mutagenesis [7].

References