Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Ku80 - CG18801 gene product from transcript...

Drosophila melanogaster

Synonyms: BG:DS09217.6, CG18801, DmKu80, Dmel\CG18801, KU80, ...

Melnikova, L. et al., Robert, V. et al., Min, B. et al.

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High impact information on Ku80

Analysis of DSB repair during MosTIC experiments demonstrated that DSBs could also be sealed by end-joining in the germ line, independently from the evolutionarily conserved Ku80 and ligase IV factors [1].
We have used RNA interference (RNAi) to knock down expression of DmBLM and one or both of the Drosophila Ku subunits, DmKu70 or DmKu80 [2].

Biological context of Ku80

Here we show that a decrease in Ku70 or Ku80 gene dosage causes a sharp increase in the frequency of HeT-A and TART attachments to a broken chromosome end and in terminal DNA elongation by gene conversion [3].

Other interactions of Ku80

Loss of Ku80 has more pronounced effects than loss of Ku70 [3].

References

Targeted engineering of the Caenorhabditis elegans genome following Mos1-triggered chromosomal breaks. Robert, V., Bessereau, J.L. EMBO J. (2007) [Pubmed]
Interplay between Drosophila Bloom's syndrome helicase and Ku autoantigen during nonhomologous end joining repair of P element-induced DNA breaks. Min, B., Weinert, B.T., Rio, D.C. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
The Ku protein complex is involved in length regulation of Drosophila telomeres. Melnikova, L., Biessmann, H., Georgiev, P. Genetics (2005) [Pubmed]

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