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Gene Review:

AFUA_6G03480 - nonribosomal peptide synthase

Aspergillus fumigatus Af293

Reeves, E.P. et al., Maiya, S. et al., Schwecke, T. et al., Balibar, C.J. et al.

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High impact information on AFUA_6G03480

GliP, a Multimodular Nonribosomal Peptide Synthetase in Aspergillus fumigatus, Makes the Diketopiperazine Scaffold of Gliotoxin [1].
A phylogenetic analysis of both NRPSs and associated L-N5-ornithine monooxygenases revealed that ferrichrome-type siderophore biosynthesis has coevolved in fungi with varying in trans interactions of NRPS domains [2].
A gene encoding a putative dimodular nonribosomal peptide synthetase (NRPS) was identified within a gene cluster of Aspergillus fumigatus, a species reported to produce fumitremorgins and other prenylated alkaloids [3].
The Aspergillus fumigatus genome contains 14 nonribosomal peptide synthetase genes, potentially responsible for generating metabolites that contribute to organismal virulence [4].
A nonribosomal peptide synthetase (Pes1) confers protection against oxidative stress in Aspergillus fumigatus [4].

References

GliP, a Multimodular Nonribosomal Peptide Synthetase in Aspergillus fumigatus, Makes the Diketopiperazine Scaffold of Gliotoxin. Balibar, C.J., Walsh, C.T. Biochemistry (2006) [Pubmed]
Nonribosomal peptide synthesis in Schizosaccharomyces pombe and the architectures of ferrichrome-type siderophore synthetases in fungi. Schwecke, T., Göttling, K., Durek, P., Dueñas, I., Käufer, N.F., Zock-Emmenthal, S., Staub, E., Neuhof, T., Dieckmann, R., von Döhren, H. Chembiochem (2006) [Pubmed]
The fumitremorgin gene cluster of Aspergillus fumigatus: identification of a gene encoding brevianamide F synthetase. Maiya, S., Grundmann, A., Li, S.M., Turner, G. Chembiochem (2006) [Pubmed]
A nonribosomal peptide synthetase (Pes1) confers protection against oxidative stress in Aspergillus fumigatus. Reeves, E.P., Reiber, K., Neville, C., Scheibner, O., Kavanagh, K., Doyle, S. FEBS J. (2006) [Pubmed]

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