Psychiatry related information on pigeon

• The perception of odors or electroshock remained normal when the lio+ transgene was expressed in these lio1 flies [1].
• Sensory and motor systems (olfactory acuity and shock reactivity) required for the classical conditioning experiments were normal in mutant linotte flies--indicating that the mutation disrupts learning/memory specifically [2].

High impact information on pigeon

• The lio transcription unit was identified via rescue of the lio1 learning/memory defect by induced expression of a lio+ transgene in adults [1].
• The linotte (lio) gene was identified in a screen for mutations that disrupted 3 hr memory after olfactory associative learning, without affecting the perception of odors or electroshock [1].
• The receptor tyrosine kinase gene linotte is required for neuronal pathway selection in the Drosophila mushroom bodies [3].
• The lio gene encodes a putative receptor tyrosine kinase, with unique motifs both in the extracellular and catalytic domains (Dura, J.-M., Préat, T., Tully, T., 1993. Identification of linotte, a new gene affecting learning and memory in Drosophila melanogaster. J. Neurogenet. 9, 1-14) [4].
• A chromosomal deficiency of the 37D region, where the linotte P insert was localized in situ, failed to complement linotte's memory defect, and flies from two lines homozygous for independent PlacW excisions show normal memory--indicating that the P insertion is responsible for the mutant phenotype [2].

Analytical, diagnostic and therapeutic context of pigeon

• Sequence analysis indicates that lio encodes a novel protein [1].

References