Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

smarca4a - SWI/SNF related, matrix associated, actin...

Danio rerio

Synonyms: SO:0000704, brg1, smarca2, smarca4, wu:fb51a08

Eroglu, B. et al., Gregg, R.G. et al.

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High impact information on smarca4

Our analysis indicates that brg1 is required for the wave of mitogen-activated protein kinase activity that precedes retinal cell differentiation [1].
Here we demonstrate that a mutation in a brahma-related gene (brg1) is responsible for the yng phenotype [1].
Brg1 is a maternal factor, and brg1-deficient embryos bearing the yng mutation derived from heterozygote intercrosses exhibit lesser effects on neural crest-specific gene expression, but show defects in neurogenesis and neural crest cell differentiation [2].

References

Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiation. Gregg, R.G., Willer, G.B., Fadool, J.M., Dowling, J.E., Link, B.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
Critical role of Brg1 member of the SWI/SNF chromatin remodeling complex during neurogenesis and neural crest induction in zebrafish. Eroglu, B., Wang, G., Tu, N., Sun, X., Mivechi, N.F. Dev. Dyn. (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

SMARCA4	Bos taurus
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SMARCA4	Homo sapiens
SMARCA4	Macaca mulatta
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Smarca4	Rattus norvegicus

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