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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ths  -  thisbe

Drosophila melanogaster

Synonyms: CG12443, DFGF8-1, DmThs, Dmel\CG12443, FGF8-like1, ...
 
 
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High impact information on ths

  • Embryos that lack ths+ and pyr+ exhibit defects related to those seen in htl mutants, including delayed mesodermal migration during gastrulation and a loss of cardiac tissues and hindgut musculature [1].
  • pyramus and thisbe: FGF genes that pattern the mesoderm of Drosophila embryos [1].
  • CONCLUSIONS: We conclude that FGF8-like1 and FGF8-like2 encode two novel Drosophila FGF homologs, which are required for mesodermal cell migration during gastrulation [2].
 

Biological context of ths

  • We show that FGF8-like1 and FGF8-like2 are expressed in the neuroectoderm during gastrulation and present evidence that both act in concert to direct cell shape changes during mesodermal cell migration and are required for the activation of the Htl signaling cascade during gastrulation [2].
 

Other interactions of ths

References

  1. pyramus and thisbe: FGF genes that pattern the mesoderm of Drosophila embryos. Stathopoulos, A., Tam, B., Ronshaugen, M., Frasch, M., Levine, M. Genes Dev. (2004) [Pubmed]
  2. FGF8-like1 and FGF8-like2 encode putative ligands of the FGF receptor Htl and are required for mesoderm migration in the Drosophila gastrula. Gryzik, T., Müller, H.A. Curr. Biol. (2004) [Pubmed]
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