Gene Review:
pyr - pyramus
Drosophila melanogaster
Synonyms:
CG13194, DFGF8-2, DmPyr, Dmel\CG13194, FGF8-like2, ...
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High impact information on pyr
- We show that FGF8-like1 and FGF8-like2 are expressed in the neuroectoderm during gastrulation and present evidence that both act in concert to direct cell shape changes during mesodermal cell migration and are required for the activation of the Htl signaling cascade during gastrulation [1].
- FGF8-like1 and FGF8-like2 encode putative ligands of the FGF receptor Htl and are required for mesoderm migration in the Drosophila gastrula [1].
- CONCLUSIONS: We conclude that FGF8-like1 and FGF8-like2 encode two novel Drosophila FGF homologs, which are required for mesodermal cell migration during gastrulation [1].
Biological context of pyr
- We identified two genes, FGF8-like1 and FGF8-like2, that encode novel FGF homologs and were only partially annotated in the Drosophila genome [1].
Other interactions of pyr
- Our results suggest that FGF8-like1 and FGF8-like2 represent ligands of the Htl FGF receptor [1].
References
- FGF8-like1 and FGF8-like2 encode putative ligands of the FGF receptor Htl and are required for mesoderm migration in the Drosophila gastrula. Gryzik, T., Müller, H.A. Curr. Biol. (2004) [Pubmed]
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