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Gene Review

fra  -  frazzled

Drosophila melanogaster

Synonyms: CG8581, CT24981, DCC, Dmel\CG8581, Fra
 
 
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High impact information on fra

  • We have rescued the frazzled CNS and motor axon defects by expressing Frazzled specifically in neurons; expression in target tissues does not rescue the phenotype [1].
  • Null mutants in frazzled are defective in axon guidance in the central nervous system and in motor axon guidance and targeting in the periphery [1].
  • The frazzled gene encodes transmembrane proteins that contain four immunoglobulin C2 type domains, six fibronectin type III repeats, and a cytoplasmic domain of 278 amino acids [1].
  • Mutations in Abl and trio dominantly enhance fra and Netrin mutant CNS phenotypes, and fra;Abl and fra;trio double mutants display a dramatic loss of axons in a majority of commissures [2].
  • The netrin receptor frazzled is required in the target for establishment of retinal projections in the Drosophila visual system [3].
 

Biological context of fra

  • Analysis of the AcGq3 phenotype in roundabout and frazzled mutants shows that AcGq3 function is antagonistic to Robo signaling and requires Frazzled to promote ectopic midline crossing [4].
  • Finally, we identified a small genomic fragment within intron 1 of frazzled that can mediate activation by Engrailed in vivo when fused to a GFP reporter [5].
 

Regulatory relationships of fra

References

  1. frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. Kolodziej, P.A., Timpe, L.C., Mitchell, K.J., Fried, S.R., Goodman, C.S., Jan, L.Y., Jan, Y.N. Cell (1996) [Pubmed]
  2. The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in Drosophila. Forsthoefel, D.J., Liebl, E.C., Kolodziej, P.A., Seeger, M.A. Development (2005) [Pubmed]
  3. The netrin receptor frazzled is required in the target for establishment of retinal projections in the Drosophila visual system. Gong, Q., Rangarajan, R., Seeger, M., Gaul, U. Development (1999) [Pubmed]
  4. Altered levels of Gq activity modulate axonal pathfinding in Drosophila. Ratnaparkhi, A., Banerjee, S., Hasan, G. J. Neurosci. (2002) [Pubmed]
  5. Engrailed controls the organization of the ventral nerve cord through frazzled regulation. Joly, W., Mugat, B., Maschat, F. Dev. Biol. (2007) [Pubmed]
 
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