Disease relevance of Neo1

• It displays a high level of similarity to Punc, as well as to guidance receptors such as the Deleted in Colorectal Cancer protein and Neogenin [1].

High impact information on Neo1

• Taken together, these results identify a crucial role for PlTPalpha in netrin-1-induced neurite outgrowth, revealing a signalling mechanism for DCC/neogenin and PlTPalpha regulation [2].
• We report here that myoblasts express the secreted factor netrin-3 and its receptor, neogenin [3].
• It is proposed that netrin-3 and neogenin may promote myogenic differentiation by an autocrine mechanism as components of a higher order complex of several promyogenic cell surface proteins [3].
• Netrins and neogenin promote myotube formation [3].
• Netrin and its receptor Neogenin are thought to be regulators of axonal guidance in the nervous system [4].

Chemical compound and disease context of Neo1

• The migrating cells also expressed the netrin receptors neogenin and Deleted in Colorectal Carcinoma (DCC) [5].

Biological context of Neo1

• Recent studies have begun to uncover a role for Neogenin in organogenesis [6].
• Localization of Neogenin protein during morphogenesis in the mouse embryo [6].
• Mouse Neogenin, a DCC-like molecule, has four splice variants and is expressed widely in the adult mouse and during embryogenesis [7].
• We describe three alternatively spliced exons within the extracellular domain of Neogenin and a fourth alternatively spliced exon within the cytoplasmic domain [7].
• These observations suggests that Neogenin may play an integral role in regulating differentiation programmes and/or cell migration events within many embryonic and adult tissues [7].

Anatomical context of Neo1

• In contrast, neogenin-negative forebrain cells did not produce long-term neurosphere cultures and did not possess a significant neurogenic potential [8].
• Neogenin is also seen in differentiating skeletal muscle and condensing cartilage throughout the embryo, and in the trigeminal and dorsal root ganglia of the peripheral nervous system [6].
• In some embryonic epithelia such as the gut and pancreas, Neogenin protein is predominantly polarized to the basal surfaces of the epithelial cells [6].
• Mouse Neo1 mRNA was detectable in the 18 tissues tested, the highest signals being evident in the ovary, uterus, and testis [9].
• Moreover, Hjv and Neo1 mRNAs are simultaneously expressed in skeletal muscle, heart, esophagus, and liver [9].

Associations of Neo1 with chemical compounds

• The spatial and temporal expression patterns of netrin receptors, DCC and neogenin, in the developing mouse retina [10].
• Interestingly, dynorphin, neogenin, and synaptotagmin VII, genes that possess cAMP-response element binding protein and AP-1 transcription complex-binding consensus sequences in their promoters, are also oppositely regulated by the D1 and D3 receptors after repeated exposure to cocaine [11].

Regulatory relationships of Neo1

• Hepcidin is an important iron regulatory hormone, and hemojuvelin may regulate hepcidin synthesis via the multifunctional membrane receptor neogenin [9].

Other interactions of Neo1

• We explored the expression of murine hemojuvelin and neogenin mRNAs and protein [9].

Analytical, diagnostic and therapeutic context of Neo1

• Neogenin-positive progenitors were isolated from embryonic day 14.5 forebrain using flow cytometry and cultured as neurospheres [8].
• In situ hybridization studies on day 15.5 mouse embryos revealed that Neogenin is expressed widely throughout the developing mouse embryo, in both neuronal and non-neuronal tissues [7].

References