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Gene Review

NEO1  -  neogenin 1

Gallus gallus

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Disease relevance of NEO1

  • Dorsal root ganglion axons are unresponsive to RGM but are converted to a responsive state by neogenin expression [1].
  • Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer [2].

High impact information on NEO1


Biological context of NEO1

  • Surprisingly, neogenin over-expression or RGM down-expression in the neural tube induces apoptosis [3].
  • These parallels suggest that neogenin, like DCC, is functionally involved in the transition from cell proliferation to terminal differentiation of specific cell types [2].
  • We showed previously that RGMa is a cell-survival factor in the neuroepithelium of chick embryos that suppresses the proapoptotic activity of its receptor neogenin [4].
  • Neogenin is also expressed in other embryonic tissues, suggesting a more general role in developmental processes such as tissue growth regulation, cell-cell recognition, and cell migration [5].

Anatomical context of NEO1


Physical interactions of NEO1

  • Thus, RGM/neogenin is a novel dependence ligand/receptor couple as well as an axon guidance molecular complex [6].

Other interactions of NEO1


Analytical, diagnostic and therapeutic context of NEO1

  • As revealed by antibody staining of tissue sections and Western blots, neogenin expression correlates with the onset of neuronal differentiation [2].


  1. Neogenin mediates the action of repulsive guidance molecule. Rajagopalan, S., Deitinghoff, L., Davis, D., Conrad, S., Skutella, T., Chedotal, A., Mueller, B.K., Strittmatter, S.M. Nat. Cell Biol. (2004) [Pubmed]
  2. Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer. Vielmetter, J., Kayyem, J.F., Roman, J.M., Dreyer, W.J. J. Cell Biol. (1994) [Pubmed]
  3. RGM and its receptor neogenin regulate neuronal survival. Matsunaga, E., Tauszig-Delamasure, S., Monnier, P.P., Mueller, B.K., Strittmatter, S.M., Mehlen, P., Chédotal, A. Nat. Cell Biol. (2004) [Pubmed]
  4. Repulsive guidance molecule plays multiple roles in neuronal differentiation and axon guidance. Matsunaga, E., Nakamura, H., Chédotal, A. J. Neurosci. (2006) [Pubmed]
  5. Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23. Vielmetter, J., Chen, X.N., Miskevich, F., Lane, R.P., Yamakawa, K., Korenberg, J.R., Dreyer, W.J. Genomics (1997) [Pubmed]
  6. Repulsive guidance molecule/neogenin: a novel ligand-receptor system playing multiple roles in neural development. Matsunaga, E., Chédotal, A. Dev. Growth Differ. (2004) [Pubmed]
  7. Identification and characterization of neogenin, a DCC-related gene. Meyerhardt, J.A., Look, A.T., Bigner, S.H., Fearon, E.R. Oncogene (1997) [Pubmed]
  8. Characterization of Netrin-1, Neogenin and cUNC-5H3 expression during chick dorsal root ganglia development. Guan, W., Condic, M.L. Gene Expr. Patterns (2003) [Pubmed]
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