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Gene Review:

TppII - tripeptidyl-peptidase II

Drosophila melanogaster

Synonyms: CG3991, Dmel\CG3991, TPP II, TPP-2, TPP-II, ...

Rockel, B. et al., Rockel, B. et al., Renn, S.C. et al.

Rockel, Peters, Müller, Seyit, Ringler, Hegerl, Glaeser, Baumeister,

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Disease relevance of TppII

This spindle also forms when TPPII is heterologously expressed in Escherichia coli, demonstrating that no scaffolding protein is required for complex formation and length determination [1].

High impact information on TppII

Tripeptidyl peptidase II (TPP II) is an exopeptidase of the subtilisin type of serine proteases that is thought to act downstream of the proteasome in the ubiquitin-proteasome pathway [2].
The substrate specificity and the inhibitor sensitivity of dTPP II is comparable to that of the human enzyme [3].

Analytical, diagnostic and therapeutic context of TppII

A giant protease with a twist: the TPP II complex from Drosophila studied by electron microscopy [2].
Here, we report the 900-fold purification of TPP II from Drosophila eggs and demonstrate via cryo-electron microscopy that TPP II from Drosophila melanogaster also forms a giant protease complex [2].

References

Molecular architecture and assembly mechanism of Drosophila tripeptidyl peptidase II. Rockel, B., Peters, J., Müller, S.A., Seyit, G., Ringler, P., Hegerl, R., Glaeser, R.M., Baumeister, W. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
A giant protease with a twist: the TPP II complex from Drosophila studied by electron microscopy. Rockel, B., Peters, J., Kühlmorgen, B., Glaeser, R.M., Baumeister, W. EMBO J. (2002) [Pubmed]
Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster. Renn, S.C., Tomkinson, B., Taghert, P.H. J. Biol. Chem. (1998) [Pubmed]

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