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Gene Review

TppII  -  tripeptidyl-peptidase II

Drosophila melanogaster

Synonyms: CG3991, Dmel\CG3991, TPP II, TPP-2, TPP-II, ...
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Disease relevance of TppII

  • This spindle also forms when TPPII is heterologously expressed in Escherichia coli, demonstrating that no scaffolding protein is required for complex formation and length determination [1].

High impact information on TppII


Analytical, diagnostic and therapeutic context of TppII


  1. Molecular architecture and assembly mechanism of Drosophila tripeptidyl peptidase II. Rockel, B., Peters, J., Müller, S.A., Seyit, G., Ringler, P., Hegerl, R., Glaeser, R.M., Baumeister, W. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. A giant protease with a twist: the TPP II complex from Drosophila studied by electron microscopy. Rockel, B., Peters, J., Kühlmorgen, B., Glaeser, R.M., Baumeister, W. EMBO J. (2002) [Pubmed]
  3. Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster. Renn, S.C., Tomkinson, B., Taghert, P.H. J. Biol. Chem. (1998) [Pubmed]
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