Gene Review:
Tpp2 - tripeptidyl peptidase II
Mus musculus
Synonyms:
TPP-2, TPP-II, TppII, Tripeptidyl aminopeptidase, Tripeptidyl-peptidase 2, ...
- Tripeptidyl peptidase II promotes maturation of caspase-1 in Shigella flexneri-induced macrophage apoptosis. Hilbi, H., Puro, R.J., Zychlinsky, A. Infect. Immun. (2000)
- Effect of cancer cachexia on the activity of tripeptidyl-peptidase II in skeletal muscle. Chand, A., Wyke, S.M., Tisdale, M.J. Cancer Lett. (2005)
- Tumors acquire inhibitor of apoptosis protein (IAP)-mediated apoptosis resistance through altered specificity of cytosolic proteolysis. Hong, X., Lei, L., Glas, R. J. Exp. Med. (2003)
- Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation. York, I.A., Bhutani, N., Zendzian, S., Goldberg, A.L., Rock, K.L. J. Immunol. (2006)
- PepN, the major Suc-LLVY-AMC-hydrolyzing enzyme in Escherichia coli, displays functional similarity with downstream processing enzymes in Archaea and eukarya. Implications in cytosolic protein degradation. Chandu, D., Kumar, A., Nandi, D. J. Biol. Chem. (2003)
- Characterization of cDNA for murine tripeptidyl-peptidase II reveals alternative splicing. Tomkinson, B. Biochem. J. (1994)
- The gene encoding tripeptidyl peptidase II maps to chromosome 1 in the mouse. Bermingham, N.A., McKay, T., Hoyle, J., Hernandez, D., Martin, J.E., Fisher, E.M. Mamm. Genome (1996)
- The insert within the catalytic domain of tripeptidyl-peptidase II is important for the formation of the active complex. Tomkinson, B., Ní Laoi, B., Wellington, K. Eur. J. Biochem. (2002)
- Effect of Tri-O-cresyl phosphate (TOCP) on proteolytic enzyme activities in mouse liver in vivo. Saleem, M.A., Williams, F.M., Wilkins, R.M., Shakoori, A.R., Mantle, D. J. Environ. Pathol. Toxicol. Oncol. (1998)
- Tripeptidyl peptidase-I is essential for the degradation of sulphated cholecystokinin-8 (CCK-8S) by mouse brain lysosomes. Warburton, M.J., Bernardini, F. Neurosci. Lett. (2002)