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Gene Review

Tpp2  -  tripeptidyl peptidase II

Rattus norvegicus

Synonyms: TPP-2, TPP-II, Tripeptidyl aminopeptidase, Tripeptidyl-peptidase 2, Tripeptidyl-peptidase II
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Disease relevance of Tpp2


High impact information on Tpp2


Chemical compound and disease context of Tpp2


Biological context of Tpp2


Anatomical context of Tpp2


Associations of Tpp2 with chemical compounds

  • Since it had previously been demonstrated that the enzyme can inactivate enkephalins and dynorphins in vitro by removing the N-terminal Tyr-Gly-Gly peptide, we wanted to see whether TPP II could be involved in this process also in vivo [6].

Analytical, diagnostic and therapeutic context of Tpp2


  1. Tripeptidyl-peptidase II expression and activity are increased in skeletal muscle during sepsis. Wray, C.J., Tomkinson, B., Robb, B.W., Hasselgren, P.O. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  2. Proteolysis of glucagon within hepatic endosomes by membrane-associated cathepsins B and D. Authier, F., Mort, J.S., Bell, A.W., Posner, B.I., Bergeron, J.J. J. Biol. Chem. (1995) [Pubmed]
  3. Purification, substrate specificity, and classification of tripeptidyl peptidase II. Bålöw, R.M., Tomkinson, B., Ragnarsson, U., Zetterqvist, O. J. Biol. Chem. (1986) [Pubmed]
  4. Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors. Ganellin, C.R., Bishop, P.B., Bambal, R.B., Chan, S.M., Leblond, B., Moore, A.N., Zhao, L., Bourgeat, P., Rose, C., Vargas, F., Schwartz, J.C. J. Med. Chem. (2005) [Pubmed]
  5. Immunolocalization of tripeptidyl peptidase II, a cholecystokinin-inactivating enzyme, in rat brain. Facchinetti, P., Rose, C., Rostaing, P., Triller, A., Schwartz, J.C. Neuroscience (1999) [Pubmed]
  6. Distribution of tripeptidyl-peptidase II in the central nervous system of rat. Tomkinson, B., Nyberg, F. Neurochem. Res. (1995) [Pubmed]
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