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Gene Review:

NA - neuraminidase

Influenza A virus (A/goose/Guangdong/1/1996(H5N1))

Lu, J.H. et al., Xu, X. et al., Nayak, D.P. et al., Neumann, G. et al.

Xu, Subbarao, Cox, Guo,

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Disease relevance of NA

In addition to bud completion, influenza virus requires NA to release virus particles from sialic acid residues on the cell surface and spread from cell to cell [1].
Key words: avian influenza; hemagglutinin; neuraminidase; Influenza A virus; reverse genetics; reassortment; cleavage motif; phenotype; WSN strain [2].

High impact information on NA

Similarly, two cassettes encoding the hemagglutinin and neuraminidase segments and six cassettes encoding the remaining proteins were combined [3].
Notably, the neuraminidase gene did no have the 19-amino-acid deletion in the stalk region seen in the H5N1 Hong Kong viruses and the NS gene belonged to allele B, while that of the H5N1 Hong Kong viruses belonged to allele A [4].
The results demonstrated that the reassortants did not produce CPE on MDCK cells in the absence of trypsin, showed egg-adaptation phenotype and stability of HA and NA during consecutive egg passages, and were not lethal to chickens and mice [2].

References

Assembly and budding of influenza virus. Nayak, D.P., Hui, E.K., Barman, S. Virus Res. (2004) [Pubmed]
Reassortment and modification of hemagglutinin cleavage motif of avian/wsn influenza viruses generated by reverse genetics that correlate with attenuation. Lu, J.H., Long, J.X., Jia, L.J., Liu, Y.L., Shao, W.X., Zhang, Y.M., Liu, X.F. Acta Virol. (2006) [Pubmed]
An improved reverse genetics system for influenza A virus generation and its implications for vaccine production. Neumann, G., Fujii, K., Kino, Y., Kawaoka, Y. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong. Xu, X., Subbarao, n.u.l.l., Cox, N.J., Guo, Y. Virology (1999) [Pubmed]

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