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MeSH Review

Hong Kong

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Disease relevance of Hong Kong


Psychiatry related information on Hong Kong


High impact information on Hong Kong

  • SARS: experience at Prince of Wales Hospital, Hong Kong [11].
  • The Hong Kong Academy of Medicine [12].
  • Double-blind comparison of methadone and placebo maintenance treatments of narcotic addicts in Hong Kong [13].
  • The six internal genes of B/Yamanashi/166/98 were used as the backbone to generate 6 + 2 reassortants including the HA and NA gene segments from B/Victoria/504/2000, B/Hong Kong/330/2001, and B/Hawaii/10/2001 [14].
  • The three-dimensional structures of avian H5 and swine H9 influenza hemagglutinins (HAs) from viruses closely related to those that caused outbreaks of human disease in Hong Kong in 1997 and 1999 were determined bound to avian and human cell receptor analogs [15].

Chemical compound and disease context of Hong Kong


Biological context of Hong Kong


Anatomical context of Hong Kong


Associations of Hong Kong with chemical compounds

  • In the present study, we demonstrate that ERAD of the misfolded genetic variant-null Hong Kong alpha1-antitrypsin is enhanced by overexpression of the ER processing alpha1,2-mannosidase (ER ManI) in HEK 293 cells, indicating the importance of ER ManI in glycoprotein quality control [31].
  • CONCLUSION/INTERPRETATION: Relatively low arterial pressures and blood cholesterol are likely contributors to the notably low arterial disease rates in this Chinese diabetic cohort; they reflect low rates in the Chinese mainland general population and resemble the Tokyo and Hong Kong centres of the WHO MSVDD [32].
  • Ten of the original centres (Warsaw, Berlin, Havana, Arizona, Oklahoma, Hong Kong, Switzerland, London, Tokyo, Zagreb) were able to identify the life/death status of their study participants on 1 January 1983, giving an average follow-up period of six to seven years [33].
  • Rapid increase in the prevalence of undiagnosed diabetes and impaired fasting glucose in asymptomatic Hong Kong Chinese [34].
  • Plasma testosterone levels during chronic heroin use and protracted astinence. A study of Hong Kong addicts [35].

Gene context of Hong Kong

  • PURPOSE: This study evaluated the mutational profile of epidermal growth factor receptor (EGFR) and KRAS in non-small cell lung cancers in Hong Kong and determined their relation with smoking history and other clinicopathologic features [36].
  • Associations between IL12B polymorphisms and tuberculosis in the Hong Kong Chinese population [37].
  • Association of interferon gamma and interleukin 10 genes with tuberculosis in Hong Kong Chinese [38].
  • Associations of IFN-gamma -179 (G/T), +874 (A/T), +875 miscrosatellite CA repeats and +4766 (C/T), and IL-10 -1082 (A/G), -819 (C/T) and -592 (C/A) with tuberculosis (TB) were investigated in 385 HIV-negative patients and 451 controls in a Hong Kong Chinese population [38].
  • Hybridization of Southern blots revealed that far1 was not located on the chromosome or plasmid content of a limited number of Australian, UK and Hong Kong fusidic acid-resistant isolates [39].

Analytical, diagnostic and therapeutic context of Hong Kong


  1. Plasma Epstein-Barr virus DNA and residual disease after radiotherapy for undifferentiated nasopharyngeal carcinoma. Chan, A.T., Lo, Y.M., Zee, B., Chan, L.Y., Ma, B.B., Leung, S.F., Mo, F., Lai, M., Ho, S., Huang, D.P., Johnson, P.J. J. Natl. Cancer Inst. (2002) [Pubmed]
  2. The evolution of H5N1 influenza viruses in ducks in southern China. Chen, H., Deng, G., Li, Z., Tian, G., Li, Y., Jiao, P., Zhang, L., Liu, Z., Webster, R.G., Yu, K. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Mapping of the influenza virus genome: identification of the hemagglutinin and the neuraminidase genes. Palese, P., Schulman, J.L. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  4. Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Lau, S.K., Woo, P.C., Li, K.S., Huang, Y., Tsoi, H.W., Wong, B.H., Wong, S.S., Leung, S.Y., Chan, K.H., Yuen, K.Y. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  5. Hereditary hemolytic anemia caused by diverse point mutations of pyruvate kinase gene found in Japan and Hong Kong. Kanno, H., Wei, D.C., Chan, L.C., Mizoguchi, H., Ando, M., Nakahata, T., Narisawa, K., Fujii, H., Miwa, S. Blood (1994) [Pubmed]
  6. Huntington's disease in Chinese: a hypothesis of its origin. Leung, C.M., Chan, Y.W., Chang, C.M., Yu, Y.L., Chen, C.N. J. Neurol. Neurosurg. Psychiatr. (1992) [Pubmed]
  7. Depressive symptoms and smoking among Hong Kong Chinese adolescents. Lam, T.H., Stewart, S.M., Ho, S.Y., Lai, M.K., Mak, K.H., Chau, K.V., Rao, U., Salili, F. Addiction (2005) [Pubmed]
  8. The first lithium clinic in Hong Kong: a Chinese profile. Lee, S. The Australian and New Zealand journal of psychiatry. (1992) [Pubmed]
  9. Previous participation in outpatient methadone program and residential treatment outcome: a research note from Hong Kong. Cheung, Y.W., Ch'ien, J.M. Substance use & misuse. (1999) [Pubmed]
  10. Delayed neuropsychiatric impairment after carbon monoxide poisoning from burning charcoal. Lam, S.P., Fong, S.Y., Kwok, A., Wong, T., Wing, Y.K. Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine. (2004) [Pubmed]
  11. SARS: experience at Prince of Wales Hospital, Hong Kong. Tomlinson, B., Cockram, C. Lancet (2003) [Pubmed]
  12. The Hong Kong Academy of Medicine. Todd, D. Lancet (1992) [Pubmed]
  13. Double-blind comparison of methadone and placebo maintenance treatments of narcotic addicts in Hong Kong. Newman, R.G., Whitehill, W.B. Lancet (1979) [Pubmed]
  14. Rescue of influenza B virus from eight plasmids. Hoffmann, E., Mahmood, K., Yang, C.F., Webster, R.G., Greenberg, H.B., Kemble, G. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  15. X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs. Ha, Y., Stevens, D.J., Skehel, J.J., Wiley, D.C. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  16. Follow-up of the WHO Multinational Study of Vascular Disease in Diabetes: general description and morbidity. Lee, E.T., Keen, H., Bennett, P.H., Fuller, J.H., Lu, M. Diabetologia (2001) [Pubmed]
  17. Fluoroquinolone resistance among Streptococcus pneumoniae in Hong Kong linked to the Spanish 23F clone. Ho, P.L., Yam, W.C., Cheung, T.K., Ng, W.W., Que, T.L., Tsang, D.N., Ng, T.K., Seto, W.H. Emerging Infect. Dis. (2001) [Pubmed]
  18. Electron microscopy of influenza virus. A comparison of negatively stained and ice-embedded particles. Booy, F.P., Ruigrok, R.W., van Bruggen, E.F. J. Mol. Biol. (1985) [Pubmed]
  19. In vivo influenza virus-inhibitory effects of the cyclopentane neuraminidase inhibitor RJW-270201. Sidwell, R.W., Smee, D.F., Huffman, J.H., Barnard, D.L., Bailey, K.W., Morrey, J.D., Babu, Y.S. Antimicrob. Agents Chemother. (2001) [Pubmed]
  20. Carbohydrate composition of the oligosaccharide units of the haemagglutinin from the Hong Kong influenza virus A/Memphis/102/72. Ward, C.W., Gleeson, P.A., Dopheide, T.A. Biochem. J. (1980) [Pubmed]
  21. Protein C deficiency Hong Kong 1 and 2: hereditary protein C deficiency caused by two mutant alleles, a 5-nucleotide deletion and a missense mutation. Sugahara, Y., Miura, O., Yuen, P., Aoki, N. Blood (1992) [Pubmed]
  22. A new haplotype of PDCD1 is associated with rheumatoid arthritis in Hong Kong Chinese. Kong, E.K., Prokunina-Olsson, L., Wong, W.H., Lau, C.S., Chan, T.M., Alarcón-Riquelme, M., Lau, Y.L. Arthritis Rheum. (2005) [Pubmed]
  23. Epidemiology of IDDM in southern Chinese children in Hong Kong. Wong, G.W., Leung, S.S., Oppenheimer, S.J. Diabetes Care (1993) [Pubmed]
  24. Continued circulation in China of highly pathogenic avian influenza viruses encoding the hemagglutinin gene associated with the 1997 H5N1 outbreak in poultry and humans. Cauthen, A.N., Swayne, D.E., Schultz-Cherry, S., Perdue, M.L., Suarez, D.L. J. Virol. (2000) [Pubmed]
  25. Mutations in the low-density lipoprotein receptor gene in Chinese familial hypercholesterolemia patients. Mak, Y.T., Pang, C.P., Tomlinson, B., Zhang, J., Chan, Y.S., Mak, T.W., Masarei, J.R. Arterioscler. Thromb. Vasc. Biol. (1998) [Pubmed]
  26. Direct detection of Epstein-Barr virus in peripheral blood and comparison of Epstein-Barr virus genotypes present in direct specimens and lymphoblastoid cell lines established from nasopharyngeal carcinoma patients and healthy carriers in Hong Kong. Lung, M.L., Lam, W.P., Chan, K.H., Li, S., Sham, J., Choy, D. Int. J. Cancer (1992) [Pubmed]
  27. Prognostic value of EBV markers in the clinical management of nasopharyngeal carcinoma (NPC): a multicenter follow-up study. de-Vathaire, F., Sancho-Garnier, H., de-Thé, H., Pieddeloup, C., Schwaab, G., Ho, J.H., Ellouz, R., Micheau, C., Cammoun, M., Cachin, Y. Int. J. Cancer (1988) [Pubmed]
  28. Liver cell dysplasia in association with hepatocellular carcinoma, cirrhosis and hepatitis B surface antigen in Hong Kong. Ho, J.C., Wu, P.C., Mak, T.K. Int. J. Cancer (1981) [Pubmed]
  29. Functional tumor necrosis factor-related apoptosis-inducing ligand production by avian influenza virus-infected macrophages. Zhou, J., Law, H.K., Cheung, C.Y., Ng, I.H., Peiris, J.S., Lau, Y.L. J. Infect. Dis. (2006) [Pubmed]
  30. Breast milk dioxins in Hong Kong and Pearl River Delta. Hedley, A.J., Wong, T.W., Hui, L.L., Malisch, R., Nelson, E.A. Environ. Health Perspect. (2006) [Pubmed]
  31. Enhancement of endoplasmic reticulum (ER) degradation of misfolded Null Hong Kong alpha1-antitrypsin by human ER mannosidase I. Hosokawa, N., Tremblay, L.O., You, Z., Herscovics, A., Wada, I., Nagata, K. J. Biol. Chem. (2003) [Pubmed]
  32. Vascular disease prevalence in diabetic patients in China: standardised comparison with the 14 centres in the WHO Multinational Study of Vascular Disease in Diabetes. Chi, Z.S., Lee, E.T., Lu, M., Keen, H., Bennett, P.H. Diabetologia (2001) [Pubmed]
  33. International variations in mortality among diabetic patients: the WHO Multinational Study of Vascular Disease in Diabetics. Head, J., Fuller, J.H. Diabetologia (1990) [Pubmed]
  34. Rapid increase in the prevalence of undiagnosed diabetes and impaired fasting glucose in asymptomatic Hong Kong Chinese. Ko, G.T., Wu, M.M., Wai, H.P., Tang, J., Chan, C.H., Kan, E.C., Chen, R. Diabetes Care (1999) [Pubmed]
  35. Plasma testosterone levels during chronic heroin use and protracted astinence. A study of Hong Kong addicts. Mendelson, J.H., Mello, N.K. Clin. Pharmacol. Ther. (1975) [Pubmed]
  36. Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. Tam, I.Y., Chung, L.P., Suen, W.S., Wang, E., Wong, M.C., Ho, K.K., Lam, W.K., Chiu, S.W., Girard, L., Minna, J.D., Gazdar, A.F., Wong, M.P. Clin. Cancer Res. (2006) [Pubmed]
  37. Associations between IL12B polymorphisms and tuberculosis in the Hong Kong Chinese population. Tso, H.W., Lau, Y.L., Tam, C.M., Wong, H.S., Chiang, A.K. J. Infect. Dis. (2004) [Pubmed]
  38. Association of interferon gamma and interleukin 10 genes with tuberculosis in Hong Kong Chinese. Tso, H.W., Ip, W.K., Chong, W.P., Tam, C.M., Chiang, A.K., Lau, Y.L. Genes Immun. (2005) [Pubmed]
  39. Genetic characterization of the fusidic acid and cadmium resistance determinants of Staphylococcus aureus plasmid pUB101. O'Brien, F.G., Price, C., Grubb, W.B., Gustafson, J.E. J. Antimicrob. Chemother. (2002) [Pubmed]
  40. Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group. Lee, A.W., Lau, W.H., Tung, S.Y., Chua, D.T., Chappell, R., Xu, L., Siu, L., Sze, W.M., Leung, T.W., Sham, J.S., Ngan, R.K., Law, S.C., Yau, T.K., Au, J.S., O'Sullivan, B., Pang, E.S., O, S.K., Au, G.K., Lau, J.T. J. Clin. Oncol. (2005) [Pubmed]
  41. Cantonese-style salted fish as a cause of nasopharyngeal carcinoma: report of a case-control study in Hong Kong. Yu, M.C., Ho, J.H., Lai, S.H., Henderson, B.E. Cancer Res. (1986) [Pubmed]
  42. Diversity of the antibody response to the different antigenic determinants on the hemagglutinin subunits of influenza viruses. Laver, W.G., Downie, J.C., Webster, R.G. J. Immunol. (1976) [Pubmed]
  43. C-reactive protein predicts the deterioration of glycemia in chinese subjects with impaired glucose tolerance. Tan, K.C., Wat, N.M., Tam, S.C., Janus, E.D., Lam, T.H., Lam, K.S. Diabetes Care (2003) [Pubmed]
  44. Use of the 1997 American Diabetes Association diagnostic criteria for diabetes in a Hong Kong Chinese population. Ko, G.T., Chan, J.C., Woo, J., Cockram, C.S. Diabetes Care (1998) [Pubmed]
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