High impact information on pcs

• We show that the lack of poirot activity dramatically decreases OSK protein levels, without affecting the oskar mRNA distribution [1].
• In poirot mutant oocytes, delocalised OSK protein is observed, indicating that wild-type poirot has a role in the anchoring process of the OSK protein at the posterior pole [1].
• During a systematic hobo-mediated mutant isolation screen, we identified poirot, a novel posterior group gene, owing to its germ cell-less phenotype [1].
• Loss and gain of function studies demonstrate that pcs is necessary at distinct times for muscle specification and morphogenesis [2].
• Parcas, a regulator of non-receptor tyrosine kinase signaling, acts during anterior-posterior patterning and somatic muscle development in Drosophila melanogaster [2].

Biological context of pcs

• Pcs is expressed in the ovary and oocyte during oogenesis and again in the embryo, specifically in the developing mesoderm, throughout muscle development. pcs is first required in the ovary during oogenesis for patterning and segmentation of the early Drosophila embryo due primarily to its role in the regulation of Oskar (Osk) levels [2].

References