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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Flo1  -  Flotillin 1

Drosophila melanogaster

Synonyms: CG8200, CK02126, Dmel\CG8200, FLO1, FLODM-1, ...
 
 
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High impact information on Flo

  • The requirement of Reggie1/Flo2 for Reggie2/Flo1 stabilization is confirmed by misexpression experiments [1].
  • Reggie/Flotillin proteins are upregulated after optic nerve dissection and evolutionary highly conserved components of lipid rafts [1].
  • In the wing imaginal disc, global overexpression of Reggie/Flotillin proteins leads to a significant extension of the Wingless signal and severely disrupts normal wing development [1].
  • Reggie-1 and reggie-2 are two evolutionarily highly conserved proteins which are up-regulated in retinal ganglion cells during regeneration of lesioned axons in the goldfish optic nerve [2].
  • Our current results provide a starting point and systematic basis for dissecting the role of flotillin in caveolae and neuronal development using Drosophila as a genetic system [3].
 

Other interactions of Flo

  • Caveolins (Cav-1, -2 and -3) and flotillins (FLO-1 and FLO-2 [also known as epidermal surface antigens (ESAs)] are two families of mammalian caveolae-associated integral membrane proteins [3].

References

  1. Loss- and gain-of-function analysis of the lipid raft proteins Reggie/Flotillin in Drosophila: they are posttranslationally regulated, and misexpression interferes with wing and eye development. Hoehne, M., de Couet, H.G., Stuermer, C.A., Fischbach, K.F. Mol. Cell. Neurosci. (2005) [Pubmed]
  2. The 'lipid raft' microdomain proteins reggie-1 and reggie-2 (flotillins) are scaffolds for protein interaction and signalling. Stuermer, C.A., Plattner, H. Biochem. Soc. Symp. (2005) [Pubmed]
  3. Identification, sequence and developmental expression of invertebrate flotillins from Drosophila melanogaster. Galbiati, F., Volonte, D., Goltz, J.S., Steele, Z., Sen, J., Jurcsak, J., Stein, D., Stevens, L., Lisanti, M.P. Gene (1998) [Pubmed]
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