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Gene Review

FLOT1  -  flotillin 1

Homo sapiens

Synonyms: Flotillin-1
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Disease relevance of FLOT1


Psychiatry related information on FLOT1


High impact information on FLOT1


Biological context of FLOT1


Anatomical context of FLOT1


Associations of FLOT1 with chemical compounds

  • Cell fractionation experiments revealed decreases in both cholesterol in rafts and a raft marker, flotillin, during replicative aging [14].
  • In invaginations induced by amphiphiles, the enrichment of ganglioside GM1, but not of the integral membrane proteins flotillin-1 and stomatin, was observed [15].
  • Direct interactions between resident raft proteins (caveolins and flotillin-1) and insulin-signaling molecules may organize these molecules in space and time to ensure faithful transduction of the insulin signal, at least with respect to the glucose-dependent actions of insulin in adipocytes [16].
  • Tyr160 in flotillin-1 and Tyr163 in flotillin-2 are directly phosphorylated by Fyn, and mutation of these residues to phenylalanine prevents Fyn-induced flotillin internalisation [17].

Physical interactions of FLOT1

  • Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein [8].
  • Our results show that both CAV-1 and FLOT-1 may modulate beta-secretase activity by interacting with BACE1 [18].
  • The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein [2].
  • We show here that PTOV1 interacts with the lipid raft protein flotillin-1, with which it copurifies in detergent-insoluble floating fractions [10].

Co-localisations of FLOT1


Other interactions of FLOT1

  • The interaction of Ngb with flotillin-1 was confirmed by glutathione S-transferase pull-down experiments [8].
  • The lipid-raft marker proteins flotillin-1 and flotillin-2 were also present in platelets but excluded from alpha granules [19].
  • We found that Pyk2 and Cbl interacted with the adaptor protein ArgBP2, which also bound to flotillin-1, a component of lipid raft microdomains [20].
  • Apart from the GPI-anchored proteins, the most abundant integral proteins were found to be the distantly related membrane proteins stomatin (band 7.2b), flotillin-1, and flotillin-2 [11].
  • PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts [10].

Analytical, diagnostic and therapeutic context of FLOT1


  1. Identification of flotillin-1 as a protein interacting with myocilin: implications for the pathogenesis of primary open-angle glaucoma. Joe, M.K., Sohn, S., Choi, Y.R., Park, H., Kee, C. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  2. The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein. Chen, T.Y., Liu, P.H., Ruan, C.T., Chiu, L., Kung, F.L. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  3. Expression, purification, and characterization of recombinant human flotillin-1 in Escherichia coli. Ding, Y., Jiang, M., Jiang, W., Su, Y., Zhou, H., Hu, X., Zhang, Z. Protein Expr. Purif. (2005) [Pubmed]
  4. Immunohistochemical study of flotillin-1 in the spinal cord of Lewis rats with experimental autoimmune encephalomyelitis. Kim, H., Ahn, M., Moon, C., Matsumoto, Y., Sung Koh, C., Shin, T. Brain Res. (2006) [Pubmed]
  5. Accumulation of flotillin-1 in tangle-bearing neurones of Alzheimer's disease. Girardot, N., Allinquant, B., Langui, D., Laquerrière, A., Dubois, B., Hauw, J.J., Duyckaerts, C. Neuropathol. Appl. Neurobiol. (2003) [Pubmed]
  6. Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells. Glebov, O.O., Bright, N.A., Nichols, B.J. Nat. Cell Biol. (2006) [Pubmed]
  7. The sorbin homology domain: a motif for the targeting of proteins to lipid rafts. Kimura, A., Baumann, C.A., Chiang, S.H., Saltiel, A.R. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  8. Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein. Wakasugi, K., Nakano, T., Kitatsuji, C., Morishima, I. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  9. Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells. Bared, S.M., Buechler, C., Boettcher, A., Dayoub, R., Sigruener, A., Grandl, M., Rudolph, C., Dada, A., Schmitz, G. Mol. Biol. Cell (2004) [Pubmed]
  10. PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts. Santamaría, A., Castellanos, E., Gómez, V., Benedit, P., Renau-Piqueras, J., Morote, J., Reventós, J., Thomson, T.M., Paciucci, R. Mol. Cell. Biol. (2005) [Pubmed]
  11. Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts. Salzer, U., Prohaska, R. Blood (2001) [Pubmed]
  12. The flotillins are integral membrane proteins in lipid rafts that contain TCR-associated signaling components: implications for T-cell activation. Slaughter, N., Laux, I., Tu, X., Whitelegge, J., Zhu, X., Effros, R., Bickel, P., Nel, A. Clin. Immunol. (2003) [Pubmed]
  13. Reggie/flotillin proteins are organized into stable tetramers in membrane microdomains. Solis, G.P., Hoegg, M., Munderloh, C., Schrock, Y., Malaga-Trillo, E., Rivera-Milla, E., Stuermer, C.A. Biochem. J. (2007) [Pubmed]
  14. Cellular aging-dependent decrease in cholesterol in membrane microdomains of human diploid fibroblasts. Nakamura, M., Kondo, H., Shimada, Y., Waheed, A.A., Ohno-Iwashita, Y. Exp. Cell Res. (2003) [Pubmed]
  15. Curvature-dependent lateral distribution of raft markers in the human erythrocyte membrane. Hägerstrand, H., Mrówczyńska, L., Salzer, U., Prohaska, R., Michelsen, K.A., Kralj-Iglic, V., Iglic, A. Mol. Membr. Biol. (2006) [Pubmed]
  16. Lipid rafts and insulin signaling. Bickel, P.E. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  17. Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase. Riento, K., Frick, M., Schafer, I., Nichols, B.J. J. Cell. Sci. (2009) [Pubmed]
  18. BACE1 interacts with lipid raft proteins. Hattori, C., Asai, M., Onishi, H., Sasagawa, N., Hashimoto, Y., Saido, T.C., Maruyama, K., Mizutani, S., Ishiura, S. J. Neurosci. Res. (2006) [Pubmed]
  19. Stomatin is a major lipid-raft component of platelet alpha granules. Mairhofer, M., Steiner, M., Mosgoeller, W., Prohaska, R., Salzer, U. Blood (2002) [Pubmed]
  20. Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. Haglund, K., Ivankovic-Dikic, I., Shimokawa, N., Kruh, G.D., Dikic, I. J. Cell. Sci. (2004) [Pubmed]
  21. Subcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice. Langui, D., Girardot, N., El Hachimi, K.H., Allinquant, B., Blanchard, V., Pradier, L., Duyckaerts, C. Am. J. Pathol. (2004) [Pubmed]
  22. Erythrocyte detergent-resistant membrane proteins: their characterization and selective uptake during malarial infection. Murphy, S.C., Samuel, B.U., Harrison, T., Speicher, K.D., Speicher, D.W., Reid, M.E., Prohaska, R., Low, P.S., Tanner, M.J., Mohandas, N., Haldar, K. Blood (2004) [Pubmed]
  23. Proteome analysis of lipid rafts in Jurkat cells characterizes a raft subset that is involved in NF-kappaB activation. Tu, X., Huang, A., Bae, D., Slaughter, N., Whitelegge, J., Crother, T., Bickel, P.E., Nel, A. J. Proteome Res. (2004) [Pubmed]
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