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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ITPK1  -  inositol-tetrakisphosphate 1-kinase

Homo sapiens

Synonyms: Inositol 1,3,4-trisphosphate 5/6-kinase, Inositol-tetrakisphosphate 1-kinase, Inositol-triphosphate 5/6-kinase, Ins(1,3,4)P(3) 5/6-kinase
 
 
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Disease relevance of ITPK1

  • Apical localization of ITPK1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis [1].
 

High impact information on ITPK1

  • The biological impact of this differential gene expression is amplified by ITPK1 being concentrated at the apical membrane of MTEs, which we discovered following confocal immunofluorescence microscopy [1].
  • ITPK1 synthesizes an intracellular signal, inositol (3,4,5,6)-tetrakisphosphate [Ins(3,4,5,6)P4] [1].
  • After bolus injection of two contrast agents (CA, Optison and SonoVue), perfusion-related parameters (time-to-peak intensity, Itpk, peak intensity, Ipk, and peak width, Wpk) were extracted by fitting a model function to time-intensity curves for different regions-of-interest (ROI) in 14 volunteers [2].
 

Analytical, diagnostic and therapeutic context of ITPK1

  • Real-time PCR provided the explanation: the level of ITPK1 expression in wild-type MTEs was twice as high as that in CF MTEs (P<0.002) [1].

References

  1. Apical localization of ITPK1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis. Yang, L., Reece, J., Gabriel, S.E., Shears, S.B. J. Cell. Sci. (2006) [Pubmed]
  2. Parameters of cerebral perfusion in phase-inversion harmonic imaging (PIHI) ultrasound examinations. Eyding, J., Krogias, C., Wilkening, W., Meves, S., Ermert, H., Postert, T. Ultrasound in medicine & biology. (2003) [Pubmed]
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