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ITPR2  -  inositol 1,4,5-trisphosphate receptor, type 2

Homo sapiens

Synonyms: CFAP48, IP3 receptor isoform 2, IP3R 2, IP3R2, Inositol 1,4,5-trisphosphate receptor type 2, ...
 
 
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High impact information on ITPR2

 

Associations of ITPR2 with chemical compounds

  • ITPR2 is a strong candidate susceptibility gene for ALS because it is involved in glutamate-mediated neurotransmission, is one of the main regulators of intracellular calcium concentrations, and has an important role in apoptosis [4].

References

  1. Myxoma viral serpin, Serp-1, a unique interceptor of coagulation and innate immune pathways. Viswanathan, K., Liu, L., Vaziri, S., Dai, E., Richardson, J., Togonu-Bickersteth, B., Vatsya, P., Christov, A., Lucas, A.R. Thromb. Haemost. (2006) [Pubmed]
  2. ATP-induced Ca2+ signals in bronchial epithelial cells. Sienaert, I., Huyghe, S., Parys, J.B., Malfait, M., Kunzelmann, K., De Smedt, H., Verleden, G.M., Missiaen, L. Pflugers Arch. (1998) [Pubmed]
  3. The effect of higher order RNA processes on changing patterns of protein domain selection: a developmentally regulated transcriptome of type 1 inositol 1,4,5-trisphosphate receptors. Regan, M.R., Lin, D.D., Emerick, M.C., Agnew, W.S. Proteins (2005) [Pubmed]
  4. ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study. van Es, M.A., Van Vught, P.W., Blauw, H.M., Franke, L., Saris, C.G., Andersen, P.M., Van Den Bosch, L., de Jong, S.W., van 't Slot, R., Birve, A., Lemmens, R., de Jong, V., Baas, F., Schelhaas, H.J., Sleegers, K., Van Broeckhoven, C., Wokke, J.H., Wijmenga, C., Robberecht, W., Veldink, J.H., Ophoff, R.A., van den Berg, L.H. Lancet. Neurol (2007) [Pubmed]
 
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