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Gene Review

ITPR3  -  inositol 1,4,5-trisphosphate receptor, type 3

Homo sapiens

Synonyms: IP3 receptor isoform 3, IP3R, IP3R 3, IP3R3, Inositol 1,4,5-trisphosphate receptor type 3, ...
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Disease relevance of ITPR3


High impact information on ITPR3


Anatomical context of ITPR3

  • As cells which express IP3R3 mRNA (i.e. pancreas ascinar cells) are known to have a secretory function in which IP3/Ca2+ signaling has been shown to be involved, IP3R3 may be a prerequisite for secretion of an enzyme, such as protease, in gastric cancer cells [1].

Associations of ITPR3 with chemical compounds

  • We localized a cytosolic Ca2+-binding site between amino acid residues 2077 and 2101 in the type-2 InsP3 receptor and between amino acids 2030 and 2050 in the type-3 InsP3 receptor by expressing the respective parts of these receptors as glutathione S-transferase fusion proteins in bacteria [6].


  1. Possible involvement of inositol 1,4,5-trisphosphate receptor type 3 (IP3R3) in the peritoneal dissemination of gastric cancers. Sakakura, C., Hagiwara, A., Fukuda, K., Shimomura, K., Takagi, T., Kin, S., Nakase, Y., Fujiyama, J., Mikoshiba, K., Okazaki, Y., Yamagishi, H. Anticancer Res. (2003) [Pubmed]
  2. Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in sweden. Roach, J.C., Deutsch, K., Li, S., Siegel, A.F., Bekris, L.M., Einhaus, D.C., Sheridan, C.M., Glusman, G., Hood, L., Lernmark, A., Janer, M. Am. J. Hum. Genet. (2006) [Pubmed]
  3. Primary structure, ligand binding, and localization of the human type 3 inositol 1,4,5-trisphosphate receptor expressed in intestinal epithelium. Maranto, A.R. J. Biol. Chem. (1994) [Pubmed]
  4. T-cell-receptor signalling in inositol 1,4,5-trisphosphate receptor (IP3R) type-1-deficient mice: is IP3R type 1 essential for T-cell-receptor signalling? Hirota, J., Baba, M., Matsumoto, M., Furuichi, T., Takatsu, K., Mikoshiba, K. Biochem. J. (1998) [Pubmed]
  5. The overexpression of presenilin2 and Alzheimer's-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells. Lessard, C.B., Lussier, M.P., Cayouette, S., Bourque, G., Boulay, G. Cell. Signal. (2005) [Pubmed]
  6. ATP-induced Ca2+ signals in bronchial epithelial cells. Sienaert, I., Huyghe, S., Parys, J.B., Malfait, M., Kunzelmann, K., De Smedt, H., Verleden, G.M., Missiaen, L. Pflugers Arch. (1998) [Pubmed]
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