The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Itpr1  -  inositol 1,4,5-trisphosphate receptor 1

Mus musculus

Synonyms: D6Pas2, ENSMUSG00000072853, Gm10429, IP3 receptor isoform 1, IP3R 1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Itpr1


Psychiatry related information on Itpr1


High impact information on Itpr1


Chemical compound and disease context of Itpr1


Biological context of Itpr1

  • The human homologues of the flanking loci Itpr1 (proximal) and Syn2 (distal) map to chromosome 3p25-p26, suggesting that the human homologue of the dfw gene is located within this same region [19].
  • Here, we identified hematopoietic zinc finger (Hzf) as a trans-acting factor that regulates the dendritic mRNA localization of the type 1 inositol 1,4,5-trisphosphate receptor (IP(3)RI), a dendritically localized mRNA in cerebellar Purkinje cells, via binding to the 3' UTR [20].
  • From these results, we suggest that NDRF is involved in the tissue-specific regulation of IP3R1 gene expression in the CNS [21].
  • Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1 [22].
  • These findings suggest that there is a distinct mediolateral heterogeneity in the staggerer cerebellum with respect to transcription levels of these Purkinje cell-specific molecules, which might correlate with some cytological phenotypes [23].

Anatomical context of Itpr1


Associations of Itpr1 with chemical compounds

  • The developmental expression and intracellular localization of a cerebellum-characteristic 250-kDa glycoprotein, P400 protein, were studied by immunohistochemical and immunoblot methods using a monoclonal antibody against P400 protein [25].
  • The finding of a high receptor density in the Purkinje cell masses of the rl/rl mutant, where Purkinje cells are devoid of afferent basket cell input, suggests that benzodiazepine receptors are expressed and maintained in the absence of a full complement of GABAergic afferents [27].
  • P400 protein characteristic to Purkinje cells and related proteins in cerebella from neuropathological mutant mice: autoradiographic study by 14C-leucine and phosphorylation [28].
  • Moreover, although most of the control neurons did not respond to the metabotropic glutamate receptor (mGluR) stimulation, the 2-amino-5-phosphonopentanoic acid-treated neurons with high IP3R1 expression became sensitive to mGluR stimulation [29].
  • We found that chronic blockade of NMDA receptors (NMDARs), one of the major Ca(2+)-permeable ion channels, increased the number of neurons that express a high level of IP3R1 without any apparent changes in its intracellular localization [29].

Physical interactions of Itpr1


Regulatory relationships of Itpr1


Other interactions of Itpr1


Analytical, diagnostic and therapeutic context of Itpr1


  1. Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Matsumoto, M., Nakagawa, T., Inoue, T., Nagata, E., Tanaka, K., Takano, H., Minowa, O., Kuno, J., Sakakibara, S., Yamada, M., Yoneshima, H., Miyawaki, A., Fukuuchi, Y., Furuichi, T., Okano, H., Mikoshiba, K., Noda, T. Nature (1996) [Pubmed]
  2. Demonstration of an E-box and its CNS-related binding factors for transcriptional regulation of the mouse type 1 inositol 1,4,5-trisphosphate receptor gene. Konishi, Y., Kobayashi, Y., Kishimoto, T., Makino, Y., Miyawaki, A., Furuichi, T., Okano, H., Mikoshiba, K., Tamura, T. J. Neurochem. (1997) [Pubmed]
  3. Neuronal plasticity in hippocampal mossy fiber-CA3 synapses of mice lacking the inositol-1,4,5-trisphosphate type 1 receptor. Itoh, S., Ito, K., Fujii, S., Kaneko, K., Kato, K., Mikoshiba, K., Kato, H. Brain Res. (2001) [Pubmed]
  4. A neural cell-type-specific expression system using recombinant adenovirus vectors. Hashimoto, M., Aruga, J., Hosoya, Y., Kanegae, Y., Saito, I., Mikoshiba, K. Hum. Gene Ther. (1996) [Pubmed]
  5. Direct correlation between Purkinje and granule cell number in the cerebella of lurcher chimeras and wild-type mice. Wetts, R., Herrup, K. Brain Res. (1983) [Pubmed]
  6. Exercise during development induces an increase in Purkinje cell dendritic tree size. Pysh, J.J., Weiss, G.M. Science (1979) [Pubmed]
  7. Neuronal calcium sensor-1 enhancement of InsP3 receptor activity is inhibited by therapeutic levels of lithium. Schlecker, C., Boehmerle, W., Jeromin, A., DeGray, B., Varshney, A., Sharma, Y., Szigeti-Buck, K., Ehrlich, B.E. J. Clin. Invest. (2006) [Pubmed]
  8. Role of intracellular calcium in acute thermal pain perception. Galeotti, N., Bartolini, A., Ghelardini, C. Neuropharmacology (2004) [Pubmed]
  9. Characteristics of IA currents in adult rabbit cerebellar Purkinje cells. Wang, D., Schreurs, B.G. Brain Res. (2006) [Pubmed]
  10. Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP. Zhao, L., Longo-Guess, C., Harris, B.S., Lee, J.W., Ackerman, S.L. Nat. Genet. (2005) [Pubmed]
  11. Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human. Huynh, D.P., Figueroa, K., Hoang, N., Pulst, S.M. Nat. Genet. (2000) [Pubmed]
  12. Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice. Kashiwabuchi, N., Ikeda, K., Araki, K., Hirano, T., Shibuki, K., Takayama, C., Inoue, Y., Kutsuwada, T., Yagi, T., Kang, Y. Cell (1995) [Pubmed]
  13. Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand. Bosanac, I., Alattia, J.R., Mal, T.K., Chan, J., Talarico, S., Tong, F.K., Tong, K.I., Yoshikawa, F., Furuichi, T., Iwai, M., Michikawa, T., Mikoshiba, K., Ikura, M. Nature (2002) [Pubmed]
  14. Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor. Yoshikawa, F., Morita, M., Monkawa, T., Michikawa, T., Furuichi, T., Mikoshiba, K. J. Biol. Chem. (1996) [Pubmed]
  15. Inositol 1,4,5-trisphosphate receptor immunoreactivity in SH-SY5Y human neuroblastoma cells is reduced by chronic muscarinic receptor activation. Wojcikiewicz, R.J., Nakade, S., Mikoshiba, K., Nahorski, S.R. J. Neurochem. (1992) [Pubmed]
  16. Effect of chronic ethanol ingestion on Purkinje and Golgi cell firing in vivo and on motor coordination in mice. Servais, L., Bearzatto, B., Delvaux, V., Noël, E., Leach, R., Brasseur, M., Schiffmann, S.N., Guy, C. Brain Res. (2005) [Pubmed]
  17. Neurochemical and morphological consequences of axon terminal degeneration in cerebellar deep nuclei of mice with inherited Purkinje cell degeneration. Roffler-Tarlov, S., Beart, P.M., O'Gorman, S., Sidman, R.L. Brain Res. (1979) [Pubmed]
  18. Phenytoin alters Purkinje cell axon morphology and targeting in vitro. Tauer, U., Knoth, R., Volk, B. Acta Neuropathol. (1998) [Pubmed]
  19. Physical and genetic maps of the deafwaddler region on distal mouse Chr 6. McKee-Johnson, J.W., Street, V.A., Erford, S.K., Robinson, L.C., Tempel, B.L. Genomics (1998) [Pubmed]
  20. Hzf protein regulates dendritic localization and BDNF-induced translation of type 1 inositol 1,4,5-trisphosphate receptor mRNA. Iijima, T., Imai, T., Kimura, Y., Bernstein, A., Okano, H.J., Yuzaki, M., Okano, H. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  21. Transcriptional regulation of mouse type 1 inositol 1,4,5-trisphosphate receptor gene by NeuroD-related factor. Konishi, Y., Ohkawa, N., Makino, Y., Ohkubo, H., Kageyama, R., Furuichi, T., Mikoshiba, K., Tamura, T. J. Neurochem. (1999) [Pubmed]
  22. Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1. Hirota, J., Ando, H., Hamada, K., Mikoshiba, K. Biochem. J. (2003) [Pubmed]
  23. Regional variation in expression of calbindin and inositol 1,4,5-trisphosphate receptor type 1 mRNAs in the cerebellum of the staggerer mutant mouse. Nakagawa, S., Watanabe, M., Inoue, Y. Eur. J. Neurosci. (1996) [Pubmed]
  24. Ganglioside GD1 alpha in cerebellar Purkinje cells. Its specific absence in mouse mutants with Purkinje cell abnormality and altered immunoreactivity in response to conjunctive stimuli causing long-term desensitization. Furuya, S., Irie, F., Hashikawa, T., Nakazawa, K., Kozakai, A., Hasegawa, A., Sudo, K., Hirabayashi, Y. J. Biol. Chem. (1994) [Pubmed]
  25. Developmental expression and intracellular location of P400 protein characteristic of Purkinje cells in the mouse cerebellum. Maeda, N., Niinobe, M., Inoue, Y., Mikoshiba, K. Dev. Biol. (1989) [Pubmed]
  26. Dependence of parvalbumin expression on Purkinje cell input in the deep cerebellar nuclei. Bäurle, J., Hoshi, M., Grüsser-Cornehls, U. J. Comp. Neurol. (1998) [Pubmed]
  27. Cerebellar benzodiazepine receptors: cellular localization and consequences of neurological mutations in mice. Rotter, A., Frostholm, A. Brain Res. (1988) [Pubmed]
  28. P400 protein characteristic to Purkinje cells and related proteins in cerebella from neuropathological mutant mice: autoradiographic study by 14C-leucine and phosphorylation. Mikoshiba, K., Okano, H., Tsukada, Y. Dev. Neurosci. (1985) [Pubmed]
  29. Activity-dependent expression of inositol 1,4,5-trisphosphate receptor type 1 in hippocampal neurons. Cai, W., Hisatsune, C., Nakamura, K., Nakamura, T., Inoue, T., Mikoshiba, K. J. Biol. Chem. (2004) [Pubmed]
  30. The calmodulin-binding domain in the mouse type 1 inositol 1,4,5-trisphosphate receptor. Yamada, M., Miyawaki, A., Saito, K., Nakajima, T., Yamamoto-Hino, M., Ryo, Y., Furuichi, T., Mikoshiba, K. Biochem. J. (1995) [Pubmed]
  31. The Purkinje cell degeneration 5J mutation is a single amino acid insertion that destabilizes Nna1 protein. Chakrabarti, L., Neal, J.T., Miles, M., Martinez, R.A., Smith, A.C., Sopher, B.L., La Spada, A.R. Mamm. Genome (2006) [Pubmed]
  32. The delta2 glutamate receptor: 10 years later. Yuzaki, M. Neurosci. Res. (2003) [Pubmed]
  33. Immunogold localization of phocein in dendritic spines. Haeberlé, A.M., Castets, F., Bombarde, G., Baillat, G., Bailly, Y. J. Comp. Neurol. (2006) [Pubmed]
  34. A novel isoform of beta-spectrin II localizes to cerebellar Purkinje-cell bodies and interacts with neurofibromatosis type 2 gene product schwannomin. Chen, Y., Yu, P., Lu, D., Tagle, D.A., Cai, T. J. Mol. Neurosci. (2001) [Pubmed]
  35. Growth-associated protein GAP-43 and L1 act synergistically to promote regenerative growth of Purkinje cell axons in vivo. Zhang, Y., Bo, X., Schoepfer, R., Holtmaat, A.J., Verhaagen, J., Emson, P.C., Lieberman, A.R., Anderson, P.N. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  36. The C-terminal juxtamembrane region of the delta 2 glutamate receptor controls its export from the endoplasmic reticulum. Matsuda, S., Hannen, R., Matsuda, K., Yamada, N., Tubbs, T., Yuzaki, M. Eur. J. Neurosci. (2004) [Pubmed]
  37. Course and targets of the calbindin D-28k subpopulation of primary vestibular afferents. Bäurle, J., Vogten, H., Grüsser-Cornehls, U. J. Comp. Neurol. (1998) [Pubmed]
  38. Intranasal administration of IGF-I improves behavior and Purkinje cell pathology in SCA1 mice. Vig, P.J., Subramony, S.H., D'Souza, D.R., Wei, J., Lopez, M.E. Brain Res. Bull. (2006) [Pubmed]
  39. Constitutive activation of neuronal Src causes aberrant dendritic morphogenesis in mouse cerebellar Purkinje cells. Kotani, T., Morone, N., Yuasa, S., Nada, S., Okada, M. Neurosci. Res. (2007) [Pubmed]
  40. Widespread expression of inositol 1,4,5-trisphosphate receptor type 1 gene (Insp3r1) in the mouse central nervous system. Furuichi, T., Simon-Chazottes, D., Fujino, I., Yamada, N., Hasegawa, M., Miyawaki, A., Yoshikawa, S., Guénet, J.L., Mikoshiba, K. Recept. Channels (1993) [Pubmed]
  41. Cerebellar purkinje cell loss in heterozygous rora+/- mice: a longitudinal study. Doulazmi, M., Capone, F., Frederic, F., Boukhtouche, J., Lemaigre-Dubreuil, Y., Mariani, J. J. Neurogenet. (2006) [Pubmed]
  42. Bcl-X(L) affects Ca(2+) homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors. Li, C., Fox, C.J., Master, S.R., Bindokas, V.P., Chodosh, L.A., Thompson, C.B. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  43. Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization. Parrington, J., Brind, S., De Smedt, H., Gangeswaran, R., Lai, F.A., Wojcikiewicz, R., Carroll, J. Dev. Biol. (1998) [Pubmed]
WikiGenes - Universities