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Gene Review:

5-HT1B - 5-hydroxytryptamine (serotonin) receptor 1B

Drosophila melanogaster

Synonyms: 5-HT receptor 1B, 5-HT receptor 2B, 5-HT-dro2B, 5-HT1BDro, 5-HT[1B]Dro, ...

Yuan, Q. et al., Salzet, B. et al., Obosi, L.A. et al., Chen, A. et al.

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Disease relevance of 5-HT1B

The Drosophila 5-HTdro2B receptor stimulated the metabolism of inositol phospholipid via a pertussis toxin-insensitive G-protein, but exhibited no detectable inhibition of adenylyl cyclase [1].

High impact information on 5-HT1B

We show here that this entrainment mechanism is inhibited by serotonin, acting through the Drosophila serotonin receptor 1B (d5-HT1B). d5-HT1B is expressed in clock neurons, and alterations of its levels affect molecular and behavioral responses of the clock to light [2].
The deduced amino acid sequence revealed highest identity with Drosophila melanogaster 5HT-dro2A (Z11489, 50.8%) and 5HT-dro2B (Z11490, 49.5%) receptors [3].
The first 88 amino acids of the 5HT receptor, isolated by a 5HT-affinity column followed by anion exchange chromatography and C3 reverse-phase HPLC exhibited a 43% sequence homology with Lymnaea stagnalis 5HT-receptor [4].

References

Functional characterisation of the Drosophila 5-HTdro1 and 5-HTdro2B serotonin receptors in insect cells: activation of a G(alpha) s-like protein by 5-HTdro1 but lack of coupling to inhibitory G-proteins by 5-HTdro2B. Obosi, L.A., Schuette, D.G., Europe-Finner, G.N., Beadle, D.J., Hen, R., King, L.A., Bermudez, I. FEBS Lett. (1996) [Pubmed]
Serotonin modulates circadian entrainment in Drosophila. Yuan, Q., Lin, F., Zheng, X., Sehgal, A. Neuron (2005) [Pubmed]
Molecular cloning and functional expression of a serotonin receptor from the Southern cattle tick, Boophilus microplus (Acari: Ixodidae). Chen, A., Holmes, S.P., Pietrantonio, P.V. Insect Mol. Biol. (2004) [Pubmed]
Putative leech dopamine1-like receptor molecular characterization: sequence homologies between dopamine and serotonin leech CNS receptors explain pharmacological cross-reactivities. Salzet, B., Stefano, G.B., Verger-Bocquet, M., Salzet, M. Brain Res. Mol. Brain Res. (1998) [Pubmed]

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