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Gene Review

Mgat1  -  UDP-GlcNAc:a-3-D-mannoside-beta-1,2-N...

Drosophila melanogaster

Synonyms: CG13431, Dmel\CG13431, GlcNAc-TI, GlcNAcT1, MGAT1, ...
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Disease relevance of Mgat1

  • A 1250 bp portion of the mouse cDNA encoding all but the first 34 amino acids of the deduced protein sequence was inducibly expressed in Escherichia coli and gave rise to a prominent fusion protein of mol. wt approximately 45 kDa whose presence correlated with high levels of GlcNAc-TI activity in cell lysates [1].

High impact information on Mgat1


  1. Cloning and expression of the murine gene and chromosomal location of the human gene encoding N-acetylglucosaminyltransferase I. Kumar, R., Yang, J., Eddy, R.L., Byers, M.G., Shows, T.B., Stanley, P. Glycobiology (1992) [Pubmed]
  2. Null mutations in Drosophila N-acetylglucosaminyltransferase I produce defects in locomotion and a reduced life span. Sarkar, M., Leventis, P.A., Silvescu, C.I., Reinhold, V.N., Schachter, H., Boulianne, G.L. J. Biol. Chem. (2006) [Pubmed]
  3. N-Glycans Are Involved in the Response of Caenorhabditis elegans to Bacterial Pathogens. Shi, H., Tan, J., Schachter, H. Meth. Enzymol. (2006) [Pubmed]
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