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Gene Review: 

Msx  -  homeodomain protein

Strongylocentrotus purpuratus

 
 
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High impact information on Msx

  • Regulation of Msx genes by a Bmp gradient is essential for neural crest specification [1].
  • A set of 96 homeobox transcription factors was identified in the Strongylocentrotus purpuratus genome using permissive blast searches with a large collection of authentic homeodomain sequences from mouse, human and fly [2].
  • That vertebrate Msx genes are regulated by inductive tissue interactions and growth factors suggested to us that the restriction of SpMsx gene expression to the oral ectoderm and derivatives of the vegetal plate might similarly be regulated by the series of signaling events that pattern these embryonic territories [3].

References

  1. Regulation of Msx genes by a Bmp gradient is essential for neural crest specification. Tribulo, C., Aybar, M.J., Nguyen, V.H., Mullins, M.C., Mayor, R. Development (2003) [Pubmed]
  2. Identification and characterization of homeobox transcription factor genes in Strongylocentrotus purpuratus, and their expression in embryonic development. Howard-Ashby, M., Materna, S.C., Brown, C.T., Chen, L., Cameron, R.A., Davidson, E.H. Dev. Biol. (2006) [Pubmed]
  3. The evolution of Msx gene function: expression and regulation of a sea urchin Msx class homeobox gene. Dobias, S.L., Ma, L., Wu, H., Bell, J.R., Maxson, R. Mech. Dev. (1997) [Pubmed]
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