Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

siah2 - siah E3 ubiquitin protein ligase 2

Xenopus laevis

Gutierrez, G.J. et al., Bogdan, S. et al.

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High impact information on siah2-A

On the other hand, XRINGO degradation after meiosis I is mediated by the ubiquitin ligase Siah-2, which probably requires phosphorylation of XRINGO on Ser 243 and may be important for the omission of S phase at the meiosis-I-meiosis-II transition in Xenopus oocytes [1].
Misexpression of Xsiah-2 induces a small eye phenotype in Xenopus [2].
We show that in Xenopus siah-2 is expressed maternally and is later restricted to the brain, spinal cord and the developing and mature eye [2].

References

Meiotic regulation of the CDK activator RINGO/Speedy by ubiquitin-proteasome-mediated processing and degradation. Gutierrez, G.J., V??gtlin, A., Castro, A., Ferby, I., Salvagiotto, G., Ronai, Z., Lorca, T., Nebreda, A.R. Nat. Cell Biol. (2006) [Pubmed]
Misexpression of Xsiah-2 induces a small eye phenotype in Xenopus. Bogdan, S., Senkel, S., Esser, F., Ryffel, G.U., Pogge v Strandmann, E. Mech. Dev. (2001) [Pubmed]

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